Báo cáo y học: "Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis" pptx
Báo cáo y học: "Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis" pptx
... but theywere not impaired in synovial fluid from RA patients. Our dataindicate that NKT cells may be involved in the disease processof RA and that a strategy to boost the regulatory potential ... regulatory potential of NKT cells might represent a useful candidate therapy for RA.Introduction Natural killer T (NKT) cells are a distinct subset of lymphocytesthat share the characteristics ... 3Research articlePeripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritisLoes Linsen, Marielle Thewissen, Kurt Baeten,...
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Báo cáo y học: "CCR5 signalling, but not DARC or D6 regulatory, chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway" pdf
... surface was not altered by U8 3A treatment, withminimal effects up to an hour, in contrast to stimulationwith human chemokines which showed rapid, clathrinmediated internalisation after 5 minutes ... interestsThe authors declare that they have no competing interests.Authors' contributionsJC carried out the binding, internalisation and confocalmicroscopy studies, and contributed to drafting ... CCR5 to a raft membrane microdomain, can be another pathwayto control its activity to avoid its internalisation and todirect signalling.Finally, extended CCR5 blocking could lead to enhancedU83A...
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Báo cáo y học: "Induction of tumour necrosis factor receptor-expressing macrophages by interleukin-10 and macrophage colony-stimulating factor in rheumatoid arthritis" doc
... potent ability to inhibit proinflammatory cytokinesynthesis, interleukin (IL)-10 has a marginal clinical effect in rheumatoid arthritis (RA) patients. Recent evidence suggeststhat IL-10 induces ... indicate that IL-10 may contribute tomonocyte differentiation into the proinflammatory type of mac-rophages characteristic of RA.It has been shown that IL-10 augments the macrophage col-ony-stimulating ... play an important role in both chronic inflamma-tion and joint destruction in rheumatoid arthritis (RA), princi-pally by producing many proinflammatory cytokines such astumour necrosis factor-α...
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Báo cáo y học: " Kennedy Institute of Rheumatology Division, Imperial College London, 12–13 November 2003: Towards a molecular toolkit for studying lymphocyte function in inflammatory arthritis" ppt
... http://arthritis-research.com/content/6/2/55IntroductionDespite many years of study, the aetiology of inflammatoryarthritis remains poorly understood. A growing body ofdata describing leukocyte differentiation, migration andcellular interactions has ... RAdemonstrated a defect in the ability of their CD4+CD25+ T cells to inhibit the production of TNF-α by monocytes.This defect was unchanged by treatment withmethotrexate but was restored in patients ... might initiallyexacerbate symptoms before providing benefits. This mightpartly account for the clinical improvement seen in somepatients in antibody trials after treatment was stoppedowing to...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
... originate, in thethymus or in the periphery.One prevailing model is that a class of regulatory T cells that originate in the thymus, are self-reactive and are involved in protection from autoimmune ... [10]. In mice, T R cells are thought to represent a population of T cells that are thymically derived and suppressautoreactive CD4+ T cells. This is supported by the findingthat thymectomy of ... system has evolved a variety of mechanisms to achieve and maintain tolerance bothcentrally and in the periphery. Central tolerance is achieved through negative selection ofautoreactive T cells, ...
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Báo cáo y học: "CD134 as target for specific drug delivery to T cells in adjuvant arthritis" pps
... with a cytostatic drug andadministered early in actively induced arthritis. We show thatCD134 can be used as a marker for activated auto-aggressive T cells early in AA, that targeting of these ... cells start to infiltrate thejoints [17]. The present data therefore suggest that early in AA, CD134+ T cells, after activation in the PLN, can migrate toFigure 4Anti-CD134-mediated targeting ... not lead to liposome internaliza-tion by activated CD4+ T cells in vitroAnti-CD134-mediated targeting does not lead to liposome internaliza-tion by activated CD4+ T cells in vitro. A2 b T...
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Báo cáo y học: " Transcriptome analysis of functional differentiation between haploid and diploid cells of Emiliania huxleyi, a globally significant photosynthetic calcifying cell" potx
... transcriptomesGeneral features, comparison to existing EST datasets, and analysis of transcriptome complexity and differentiationHigh quality total RNA was obtained from eight time points in the diel cycle ... spreadsheetindicating the results of automatic queries with C. reinhardtiiflagellar-related proteins against E. huxleyi EST clusters, andan analysis of these clusters compared to the KEGG database(Additional ... 10%StramenopilesViridiplantaeMetazoaProtobacteriaOther bacteriaChoanoflagellidaCyanobacteriaAmeobozoaFungiRhodophytaOther eukaryotesVirusesAlveolatesArchaea@**% of KEGG assigned clusters best-hitting...
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Báo cáo y học: " High blood pressure, antihypertensive medication and lung function in a general adult population"
... detailedanalysis of antihypertensive medication indicates that BBLmedication and not any other antihypertensive medicationis associated with a reduced lung function. This negativeeffect of ... the data analysis, interpretation of data andmanuscript preparation. JH and ES developed the statistical analysis plan. SK,HS, SG, CM, MH, AP, H-EW, JB, RMH and JH assisted in the interpretation ... function. Furthermore, our analysis indicates thatBBL medication and not any other antihypertensive treat-ment is associated with reduced lung function in a gen-eral adult population. Thus,...
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Tài liệu Báo cáo khoa học: Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process docx
... the Rac1 sequence to arginineand analyzed the mutated proteins for ubiquitination in HEK293 cells. Most of the 18 mutations tested did not notably affect the polyubiquitination pattern ofmyc–Rac1L61 ... persistently activated and associatedwith plasma membrane, Rac1b has an impaired abilityto activate several Rac1 downstream signaling path-ways [27,28]. To evaluate the possible effects of acti-vating ... proteasomal degradation. We show bymutational analysis that the main target site forRac1L61 polyubiquitination is Lys147, a surface resi-due that should not be hampered in Rac1b; we alsoreport that...
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Báo cáo y học: "Pollen allergens do not come alone: pollen associated lipid mediators (PALMS) shift the human immue systems towards a TH2-dominated respons" potx
... releasing T H2 attracting chemokines andaquire a distinct migratory phenotype. Finally, we couldshow that in a murine sensitization model, nasal instilla-tion of OVA together with aqueous pollen ... con-stituents.PALMs potently attract and activate PMN and eosinophilsThe finding that pollen grains interact with cells of thehuman immune system was made by Siegel and Shermanas early as the seventies [22]. ... able to extend theseobservations by investigating the outcome of granulocyte- pollen interactions. Our data show that pollen grains(birch and grass) attract and activate neutrophils [23] andeosinophils...
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