... Eva Balaziova1and Liliana R Sedova31Laboratory of Cancer Cell Biology of the 1stFaculty of Medicine, Charles University, Prague and the Institute of Physiology, Academy of Sciences,Prague, ... Koshiba M, Nakazawa T, Hatachi S, Saura R,Kurosaka M, Kusaka H, Kumagai S: Specific increase in enzy-matic activity of adenosine deaminase 1 in rheumatoid syn-ovial fibroblasts. Arthritis Rheum ... As the methotrexate- and deoxyco-formycin-based therapies act as anti-inflammatory agents byincreasing extracellular adenosine and blocking ADA,respectively, the presence of high soluble ADA...