Báo cáo y học: "Inhibition of antithrombin by hyaluronic acid may be involved in the pathogenesis of rheumatoid arthritis" potx
Báo cáo y học: "Inhibition of antithrombin by hyaluronic acid may be involved in the pathogenesis of rheumatoid arthritis" potx
... pathogenesis of RA. The principal plasma inhibitor of thrombin is antithrombin, asingle-chain 51 kDa glycoprotein that is synthesized in liver. The inhibitory activity of antithrombin on thrombin is ... presence of HA, supporting the notion that HA could compete withheparin for the heparin-binding region of antithrombin. Remarkably, HA affected the inhibition by antithrombin onlywithin the range ... molecularstructure of HA is analogous to that of heparin, HA mightexert its effect by binding to the heparin-binding region of antithrombin. However, such binding did not stimulate the activity of antithrombin...
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Báo cáo y học: " Respiratory difficulty caused by an ectopic brain tissue mass in the neck of a two-month-old baby: a case report" ppsx
... publication of this case report and any accompanyingimages. A copy of the written consent is available forreview by the Editor -in- Chief of this journal.Acknowledgements The author expresses sincere ... histopathological examination of the mass. The author readand approved the final manuscript.Competing interests The author declares that the y have no competing interests.Received: 4 November 2009 Accepted: ... increase in the size of this swelling and mild respiratory difficulty when the girl was sleeping. Acomputed tomography scan of the brain and neck showed a large heterogeneous mass extending from the...
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Tài liệu Báo cáo Y học: Granule-bound starch synthase I A major enzyme involved in the biogenesis of B-crystallites in starch granules ppt
... at the final stage of starch synthesis in the absence of concomitant amylopectin synthesis (reviewed in [41]). In vitrosynthesis of amyloseBecause in Chlamydomonas amylose synthesis remainsactive ... rates of amylose synthesis and we can onlystate that the latter certainly does not exceed the rate of amylopectin synthesis. The increase in crystallinity wit-nessed during these first 12 h is in ... from the results listed in Table 1 that most, if not all, of the amylose issynthesized in vivo when the rate of amylopectin synthesisbecomes minimal. At these moments the rates of amylopec-tin...
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Báo cáo y học: "Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer''''s patches in an orally tolerized, collagen-induced arthritis mouse model" ppt
... Hayaishi O:Regulation of indoleamine 2,3-dioxygenase activity in the smallintestine and the epididymis of mice. Arch Biochem Biophys1980, 203:343-351.33. Malina HZ, Martin XD: Indoleamine ... approved by the Animal ResearchEthics Committee at the Catholic University of Korea.Preparation of type II collagenBovine CII was kindly provided by Professor Andrew Kang of the University of Tennessee. ... immune inhibition in the induction of oral tolerance in the murine CIA model. We examined the change in the expression of IDO in CD11c+ DCs of Peyer's patches after repeated oraladministration...
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Báo cáo y học: " High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease." docx
... functions in vivo to enhance inflammation by binding PAMPs, DAMPs, and cytokines to promote dual-receptor interactions that may be especially effective because of their proximity. These receptors include ... consistentlyinfluenced by TNF blocking therapy with infliximab in ninestudied RA patients [76]. These findings could suggest thatHMGB1 acts upstream of TNF in the rheumatoid synovialinflammation.ConclusionAs ... receptor of the immunoglobulinsuperfamily which is activated by a variety of proinflammatoryligands, including HMGB1, advanced glycated endproducts,members of S100 proteins, and amyloid beta-peptide...
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Báo cáo y học: "Rho kinase inhibitors Y27632 and H1152 augment neurite extension in the presence of cultured Schwann cells" pdf
... cones by increasing the net phos-phorylation of the myosin regulatory light chain. It alsoactivates Rho kinase (ROCK) which directly phosphor-ylates the regulatory light chain of the major cytoplasmicmyosin, ... H1152altered the morphology of the SC. These changes weresimilar to those observed by Melendez et al [15]. They alsodescribed a shortening of the myelin segments provided by myelinating SC and ... derivative is the oldest syn-thesised and reported specific inhibitor of Rho-kinasefamily enzymes. Y2 7632 inhibits ROCK activity by com-petitive binding with ATP to the catalytic domain. Y2 7632is...
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báo cáo khoa học: " Field transcriptome revealed critical developmental and physiological transitions involved in the expression of growth potential in japonica rice" potx
... autono-mously starts independent of the development of the sink, but is accelerated by the sink formation. Delayingleaf senescence in order to maintain the photosyntheticactivity for as long ... for increasing the number of til-lers, one of the components of grain yield. The highdemand for Pi during vegetative stage may be vital forproper development of tillers and rice plants may notneed ... approximately 50% of rice plants in the fieldwere in initiation of panicle development, and at 58DAT most plants examined were already in the earlystage of panicle development, indicating that the...
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Báo cáo y học: " Protein kinase A-dependent Neuronal Nitric Oxide Synthase Activation Mediates the Enhancement of Baroreflex Response by Adrenomedullin in the Nucleus Tractus Solitarii of Rats" pps
... the possibility that the activ ation of iNOS andeNOS may be involved in ADM-induced BRR-enhancingeffect is deemed unlikely (Figure 1C &1D). Moreover,several lines of evidence support the ... activation by ADM and in NTSSince PKG can be activated by nNOS-derived NO [18],we next examined the role of PKG in the BRR enhance-ment response induced by ADM in NTS. Figure 2Ashows that co-microinjection ... after microinjection of the test agent into NTS. The BRR response was represented by the ratio of the peak magnitude of reflex bradycardia to the peak magni-tude of phenylephrine-induced pressor...
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Báo cáo y học: " HIV-1 neutralization by monoclonal antibody against conserved region 2 and patterns of epitope exposure on the surface of native viruses" pot
... results in the presence of highly immunogenic amino acids (His, Lys,Ala, Leu, Asp and Arg) within this epitope. These aminoacids occur at a greater frequency than in the C1E pep-tides. The C2E ... [25-27].Indeed, the epitopes around amino acids 93-112 and 218-239 have been previously described, including epitopes atamino acids 90-100 of C1 and 222-231 of C2. SeveralMAbs against these ... CRF01_AEC2 amino acid. Interestingly, subtype A and D also have3-4 amino acid (position 218, 227, 231, 237 or 238) dif-ferences from CRF01_AE, but they could be neutralized by MAb C2EB5 potently. The...
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Báo cáo Y học: Guanosine diphosphate-4-keto-6-deoxy-D-mannose reductase in the pathway for the synthesis of GDP-6-deoxy-D-talose in Actinobacillus actinomycetemcomitans potx
... extract was obtained by centrifugation at 20 000 g for 30 min at 4 °C. Binding of the fusion proteins to chitin beads via the intein/chitin binding domain, cleavage of the fusion protein (in 20 mMTris/HCl, ... content of 48.0% [43]. The GC content of the region essential for the biosynthesis of SPA in the otherserotype strains (b–e) of A. actinomycetemcomitans is alsolower than the average GC content of ... report on the GDP-6-deoxy-D-talose biosynthetic pathway and the role of GDP-4-keto-6-deoxy-D-mannose reductase in the synthesis of GDP-6-deoxy-D-talose.Keywords: Actinobacillus actinomycetemcomitans;6-deoxy-talose;...
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