Báo cáo y học: "Equipoise, design bias and randomized controlled trials: the elusive ethics of new drugs – a comment" pptx
Báo cáo y học: "Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development" docx
... Rheumatology; FDA = Food and Drug Administration; RCT = randomized controlled trial.Arthritis Research & Therapy Vol 6 No 3 Fries and KrishnanResearch articleEquipoise, design bias, and randomized ... consideration by a patient. This presents an idealized sequence of invitation, factual evaluation,ethical valuation, decision, and randomization. Note that factual evaluation contrasts benefits and ... (‘risk aversion’).Autonomy implies the ability to make decisions under a personal rather than an externally imposed value system.However, the standard is that of the ‘reasonable person’.Autonomy...
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Báo cáo y học: Esterified Hyaluronic Acid and Autologous Bone in the Surgical Correction of the Infra-Bone Defects"
... mesially, buccally, distally, and lingually. Data were obtained at baseline before treatment and at 10 days, and 6,9, and 24 months after treatment. Surgical Technique After local anaesthesia, ... patients with periodontal defects treated by EHA and autologous grafting, 4 males and 5 females, all non smokers, with a mean age of 43,8 years for females, 40,0 years for males and 42 years ... modulation of inflammatory cells, interaction with the proteoglycans of the extracellular matrix and scavenging of free radicals [4,5]. However, recent data indicated a certain role played by...
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Báo cáo y học: "Enhanced glutamate, IP3 and cAMP activity in the cerebral cortex of Unilateral 6-hydroxydopamine induced Parkinson’s rats: Effect of 5-HT, GABA and bone marrow cell supplementation" ppsx
... intranigrally to substantianigra individually and in combination on unilateral 6-hydroxydopamine induced Parkinson’s rat model wasanalyzed. Scatchard analysis of total glutamate and NMDA receptor ... this article as: Nandhu et al.: Enhanced glutamate, IP3 and cAMPactivity in the cerebral cortex of Unilateral 6-hydroxydopamine inducedParkinson’s rats: Effect of 5-HT, GABA and bone marrow ... with ampheta-mine on the 14thday after intranigral injection of 6-OHDA and with apomorphine on the 16thday. Ani-mals that had completed a 360◦circle towards the intact(contralateral) and...
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Báo cáo y học: "Postoperative pain scores and analgesic requirements after thyroid surgery: Comparison of three intraoperative opioid regimens"
... Waintrop C, Mourey FD, Landru JP, Eurin BG, Jacob LP. Intravenous ketoprofen in thyroid and parathyroid surgery. Anesth Analg 2001; 92:1052-7. 3. Karamanlioglu B, Arar C, Alagol A, Colak A, ... pressure measurements, respiratory frequency, pulse oximetry and temperature measurement with an infrared tympanic thermometer. The PACU staff and nurses were not aware of the analgesic assignment. ... Conclusion: After remifentanil based analgesia, anticipation of postoperative pain with opioid analgesic appears mandatory even for surgery rated as being moderately painful, otherwise longer...
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Báo cáo y học: "Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis" potx
... scanned and the intensity of each band on the gel was analyzed with IPLab Gel soft-ware (BioSystematica, Plymouth, UK). The value obtainedfor the 676-bp band in each gel was used as the cutoffpoint ... whether a correlation existedbetween the presence of free mtDNA and 8-oxodG in the SF of patients with RA and the appearance of other labo-ratory parameters, such as RF, erosivity, and extra-articularmanifestations. ... calculation is rather crude and probably an underesti-mate, because the concentration of cells in the SF and the levels of cell death vary with the severity of arthritis and the use of cytotoxic drugs. ...
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Báo cáo y học: "MMP-3 expression and release by rheumatoid arthritis fibroblast-like synoviocytes induced with a bacterial ligand of integrin α5β" pdf
... that a bacterial ligand of integrin α5β1may contribute to the aggressive behavior of RA FLSs byinducing the release of pro-inflammatory cytokines, such asIL-6, and a cartilage-degrading enzyme, ... suggest that a bacterialligand of integrin α5β1 may contribute to the aggressivebehavior of RA FLSs by inducing the release of pro-inflammatorycytokines and a cartilage-degrading enzyme, such as ... in the syno-vial tissue of patients with advanced rheumatoid arthritis orosteoarthritis: analysis with gas chromatography-mass spec-trometry and pan-bacterial polymerase chain reaction. ArthritisRheum...
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Báo cáo y học: "Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis" pdf
... proteolytic degradation of the membrane exposes matrixcomponents, facilitating binding of autoantibodies to capillary and mesangial antigens. This maintains the inflammatory reaction and continued ... compli-cated by the many levels of regulation of proteinase activity.Also, there is an emerging appreciation of considerablefunctional divergence of both MMPs and their regulators,particularly the ... Page [http://www.clip.ubc.ca]10. Imai K, Yokohama Y, Nakanishi I, Ohuchi E, Fujii Y, Nakai N,Okada Y: Matrix metalloproteinase 7 (matrilysin) from humanrectal carcinoma cells. Activation of...
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Báo cáo y học: "Adalimumab - an effective and promising treatment for patients with fistulizing Crohn’s disease: a case series" pdf
... and adalimumab as a monotherapy treatment for the long-termmaintenance of both a remission of CD and the healing of fistulas. Our main message is that the combination of ada-limumab therapy and a ... design and coordination.EIE participated in the design of the study, the acquisition and interpretation of the data and the drafting of the manuscript. PZ participated in the sequence alignment and ... description and analysis of the demographics, disease characteristics and outcome in the sub-group of patients with fistulas treated with ada-limumab, along with an evaluation of the two-yearmaintenance...
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