Báo cáo khoa học: "Update and review of the multidisciplinary management of stage IV colorectal cancer with liver metastases" docx

... citation purposes)World Journal of Surgical OncologyOpen Access Review Update and review of the multidisciplinary management of stage IV colorectal cancer with liver metastasesSherif Raafat ... The management of stage IV colorectal cancer with liver metastases has historicallyinvolved a multidisciplinary approach. In the last several decades, there have been great stridesmade in the ... day chemotherapy as allowed clinicians to pursue a moreaggressive surgical approach in the management of stage IV colorectal cancer with CLM.Additionally, locoregional and adjunctive therapies...

Tài liệu Báo cáo khoa học: Unfolding and aggregation during the thermal denaturation of streptokinase pptx

... the absence of the SK fragment. (B inset) Depend-ence with the pH of the wavelength of the maximum of the ﬂuores-cence spectra for the ANS + SK 1–63 mixtures relative to the spectrum of free ANS.Ó ... together with the lowunfolding enthalpy of the domain, is consistent with itslower degree of structure [5].Under the same equilibrium conditions, the values of Tm and DHmfor either of the ... set of parameters: a linear heat capacity function for the nativestate, Cp(N); the enthalpies and the heat capacities of the unfolded state, DHU and DCpU, and of the aggregate, DHAand...

báo cáo khoa học: "Nanofibers and nanoparticles from the insectcapturing adhesive of the Sundew (Drosera) for cell attachment" ppsx

... to the formation of tight bonding between the dried adhesive and the con-tact surface [26-30]. The stability of the dried adhesiveon the surface, combined with the non-toxic compo-nents of the ... was the elasticity of the liquid adhesive. An AFMwas employed in acoustic mode (AC) with a stop at 85%to land the tip of the c antilever on the surface of the adhesive without indenting into the ... presence of high amounts of Ca, Mg, and Cl, along with the crystallinestructure of the nanoparticles indicates that the nanoparticles are the results of salts in the adhesive.Zhang et al. Journal of...

báo cáo khoa học: " Absorption and translocation to the aerial part of magnetic carbon-coated nanoparticles through the root of different crop plants" potx

... Detail of a longitudinal section of the second internodein wheat after 24 h of exposure to bioferrofluid. r) Detail of a cross section of the second internode of pea after 48 h of exposure tobioferrofluid. ... into the treated roots and to reach the vascularcylinder in a short period of time. Study of the samplestaken at the point of application showed that after only24 hours of exposure to the bioferrofluid, ... developed for animals and humans to the plant kingdom. Effective means of nano-particles application should be identified, and the behaviour, and their movem ent and accumulationwithin the plants should...

Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx

... registrated by the integrin system, leading to a Src-dependent activation of the p38-type MAPK and thereby inhibition of autophagic proteolysis [14]. Thus, integrin-dependentcell volume sensing and signaling ... involved in the regulation of metabolism, gene expression and the susceptibilityto different kinds of stress [6]. For example, the inhibi-tion of autophagic proteolysis by insulin, glutamine and ethanol ... hormones, substrates and oxidativestress critically contribute to the regulation of metabolism, gene expression and the susceptibility to stress. Osmosensing (i.e. the registration of cellvolume)...

Tài liệu Báo cáo khoa học: Branched N-glycans regulate the biological functions of integrins and cadherins doc

... Down-regulation of the alpha-Gal epitope expression in N-gly-cans of swine endothelial cells by transfection with the N-acetylglucosaminyltransferase III gene. Modulation of the biosynthesis of terminal ... and evidence for gain- and loss- of- functions of target proteins for glycosyltransferasesinvolved in N-glycan biosynthesis: their pivotal roles ingrowth and development, cancer metastasis and ... and biological function. For example, only N-glycanslocated on either the b-propeller of a5[55] or the I-likedomain of b1or b3[68] contribute to the regulation of integrin function. Therefore,...

Tài liệu Báo cáo khoa học: Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc docx

... of biologically active derivatives with potential physiolog-ical and therapeutic implications. The present study aimed to determine the pathwaysfor the metabolism of vitamin D3 by P450scc and ... Sciences, School of Pharmacy, University of Mississippi, University, MS, USA4 Department of Pathology and Laboratory Medicine and the Center for Cancer Research, University of Tennessee Health ... [1,14]. The lack of hydroxylation of vitamin D3 atposition 22 now provides a clear explanation for the inability of P450scc to cleave the side chain of vitaminD3. Hydroxylation of the side chain of...

Tài liệu Báo cáo khoa học: Compartmentalization and in vivo insulin-induced translocation of the insulin-signaling inhibitor Grb14 in rat liver pptx

... [36]. Whether the membrane translocation of Grb14 induced by EGFinvolves the direct interaction of this protein with the activated EGF receptor or the association of the Grb14 PH domain with membrane ... tothem, the activity of a fraction of receptors lackingbound Grb14, or a combination of both. The ﬁnding that, following insulin treatment, the majority of liver Grb14 remains associated with ... catalytic activity in both compartments.ResultsSubcellular distribution of Grb14 and the IR in liver from control and insulin-injected rats The subcellular distribution of liver immunoreactiveGrb14...

Tài liệu Báo cáo khoa học: Temperature and phosphate effects on allosteric phenomena of phosphofructokinase from a hibernating ground squirrel (Spermophilus lateralis) pptx

... forallosteric activators and the values of concentration of the inhibitor that reduces control activity by 50% (I50). The enzyme showed reduced sensitivity to all activa-tors at 5 °C, the Kavalues ... stearothermophilus PFK [17], the effects on hibernator PFK are due to a change in the activation energy of the enzyme-catalyzed reactioninduced by the allosteric ligand and not by changes in the ... as the data set was typical of noncompetitive inhibition.Braxton et al. [17] previously deﬁned the effect of anallosteric ligand on Vmaxvia the use of Arrhenius plotsthat graph the ratio of...

Tài liệu Báo cáo khoa học: A point mutation in the ATP synthase of Rhodobacter capsulatus results in differential contributions of DpH and Du in driving the ATP synthesis reaction pptx

... pronounced inthecaseofthemutant.Thelargedifferencerelativetothewild-type can be best appreciated by taking the derivative of the fi tting f unctions of the mutant and wild-type data a ndplotting their ... ms(extrapolating the fittin g function when necessary). The ratios of the wild-type derivatives over the mutant, indicating the ratios of the ATPsynthesis rates, are plotted for the exp eriments in the absence ... byplotting the ratio of the fi tting f unctions of wild-type overmutant, either in the presence or in the absence of a Du,asshown in Fig. 3 C. In the presence of a Du, the differencebetween the two...

Xem thêm