... todetermine the underlying genetic defect, includingsequencing of the mitochondrial MTCYB gene.Experimental proceduresPatient detailsAll muscle biopsies and experimental procedures wereundertaken ... Budde SM, van den Heuvel LP, Janssen AJ, Smeets RJ,Buskens CA, DeMeirleir L, Van Coster R, BaethmannM, Voit T, Trijbels JM & Smeitink JA (2000) Combinedenzymatic complex I and III de ciency ... London, UK3 Nijmegen Center for Mitochondrial Disorders, Department of Pediatrics, Radboud University Nijmegen Medical Center, the Netherlands4 Department of Neurology, Royal Victoria Infirmary,...