Báo cáo y học: "Ethics of randomised controlled trials – not yet time to give up on equipoise Richard E Ashcroft" pps
Báo cáo y học: "Ethics of randomised controlled trials – not yet time to give up on equipoise Richard E Ashcroft" pps
... this?CommentaryEthics of randomised controlled trials – not yet time to give up on equipoise Richard E AshcroftMedical Ethics Unit, Imperial College London, London, UKCorresponding author: Richard E Ashcroft, ... the ‘positive expected value’ test [1]. The concept of equipoise has been introduced into the medical literature on many occasions [ 2–7 ]. Both concepts are intended to give ethical justification ... patient thetreatment the doctor believes to be best for the patient, inthe interests of scientific research and future patients.However, if there is genuine uncertainty as to which of thetreatments...
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Báo cáo y học: "Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes"
... greater than the placebo group. None of the treatment groups exhibited changes in heart rate or blood pressure relative to the control group, nor there were no differences in self-reported ... randomized placebo -controlled double-blinded study design, the absence of thermogenic changes in the placebo group, the absence of adverse effects on blood pressure, heart-rate and self-reports ... was observed over the 75 min. of the study nor were there any dif-ferences in a self-reported rating of 10 common symptoms between the treated and placebo groups. The data suggests the combination...
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Báo cáo Y học:Association of the thyrotropin receptor with calnexin, calreticulin and BiP Effects on the maturation of the receptor docx
... molecular chaperones, but the effects of these interactions on the maturation of these receptorshave not yet been determined. In the present study, it wasestablished that interactions between ... 50% of the receptors, which were not able to enter thematuration pathway were certainly degraded by theproteasome after being retanslocated into the cytosol(Fig. 2). Similar results were obtained ... published by Schubert and colleagues [20]. Theseauthors recently suggested that at least 30% of the newlysynthesized proteins were degraded by the proteasome. Thedegradation rate varied, depending...
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Báo cáo y học: " Acceptability of cancer chemoprevention trials: impact of the design" docx
... Insurance (Caisse National d’Assurance Maladie) set up a “Health Center” (“Centre de Sante”) to promote prevention and screening of diseases. Once every 5 years, these centers sent invitations to ... included con-secutive clients (both women and men) over the legal age of 18 who agreed to participate in the survey. Subjects were given a written description of the survey and were asked to ... involved in chemo-preventive trials, the design of which could however increase the acceptability rate. Key words: Research Design, Randomized Controlled Trials, Behavior, Attitude, Preventive Health...
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Báo cáo y học: "Assessment of the emotional responses produced by exposure to real food, virtual food and photographs of food in patients affected by eating disorders" ppsx
... significant effect in the subjects' degree of presence experienced in the VR condition about their level of perceived anxiety (STAI-S and VAS-A): the higher the sense of presence, the stronger the ... hypothesis, we found an effect of subjects' degree of presence experienced in the VR condi-tion on their level of perceived anxiety (STAI-S and VAS-A): the higher the sense of presence, ... compared to the baseline. Then, the differ-ences between each dependent variable measured afterthe exposure to food and the correspondent baselinewere calculated. In the case of physiological measure-ments...
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Báo cáo y học: "Use of soluble MHC class II/peptide multimers to detect antigen-specific T cells in human disease." pps
... aciddecarboxylase, T cells were tested for responses to peptide after separation with I-Ag7/peptide multimers [8].Essentially all of the reactive clones appeared to bepresent in the multimer-positive pool. ... zipper to compensate for themissing hydrophobic transmembrane regions [14]. Thepeptide can then be added to the secreted soluble mole-cules, prior to multimerization.One of the issues related ... CD4+T cells, multi-mer-positive cells have not been detected in freshly iso-lated peripheral blood cells. In nearly every case, in vitroexpansion of antigen-reactive cells has been required to document...
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Báo cáo y học: "Identification of novel genetic susceptibility loci for Behçet''''s disease using a genome-wide association study" pps
... nature and extent of function of thiscarboxypeptidase are yet to be determined. A polymorphism inthis gene would potentially affect the function of any of thepeptides cleaved by this enzyme and ... andBehçet's disease is not significant after correction for multipletesting.We next determined the genotype frequency differencesbetween patients with Behçet's disease compared with ... marked increasein cytokine production. Furthermore, double-knockout micehad increased incidence and severity of experimental autoim-mune encephalomyelitis (EAE) compared with wild-type mice[14]....
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Báo cáo y học: "Use of methotrexate therapy is not associated with decreased prevalence of metabolic syndrome" potx
... 0.009Diabetes mellitus 4.8 1.8-12.9 0.002 4.5 1.4-15.2 0.014aIn multivariate analyses, the following variables were used: gender, age, prednisolone only, methotrexate only, sulfasalazine only,hydroxychloroquine ... Research & Therapy Vol 11 No 5 Raterman et al.Page 2 of 2(page number not for citation purposes)Table 1Characteristics of the study populationMetS presentaMetS absentaMetS presentbMetS ... distribution. BMI, body mass index; CRP, C-reactive protein; DAS28, disease activity score using 28 joint counts; DMARD, disease-modifying antirheumatic drug; ESR, erythrocyte sedimentation rate; HCQ,...
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Báo cáo y học: "Use of methotrexate therapy is not associated with decreased prevalence of metabolic syndrome – authors’ respons" pps
... Research & Therapy Vol 11 No 5 Toms et al.Page 2 of 2(page number not for citation purposes)Competing interestsThe authors declare that they have no competing interests.AcknowledgementsThis ... issupported by a PhD scholarship from the Empirikion Institute, Athens,Greece.References1. Toms TE, Panoulas VF, Douglas KMJ, Kitas GD: Methotrexatetherapy associates with a reduced prevalence ... prevalence of the meta-bolic syndrome in rheumatoid arthritis patients over the age of 60: more than just an anti-inflammatory effect? A cross-sectional study. Arthritis Res Ther 2009, 11:R110.2. Toms...
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Báo cáo y học: " Divergence of exonic splicing elements after gene duplication and the impact on gene structures" pot
... important to examine the ESE and ESS changes withthe age of duplication. We use the Ka between duplicates as aproxy of duplication age. Compared to mouse, the ESEchanges are negatively correlated ... converted into their reverse andcomplementary sequences, and original ESE sequences werepurged from the converted sequences. The end result was 327real ESE and 327 control ESE motifs. The ... scanthe sequence one base at a time and detect the ESE or ESShexamers specific to either exon and those shared by bothsequences at the same position of the alignment. Assumingthat there are totally...
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