... chain (Y9 8) is almost coplanar with the face of the dimethylisoalloxazine moiety that is closer to solvent, while a tryptophan side chain (W60) is inclined atCorrespondence to S. G. Mayhew, Department ... Three-state analysis of spermwhale apomyoglobin folding. Biochemistry 32, 3790±3796.35. Pueyo, J.J., Curley, G.P. & M ayhew, S.G. (1996) Kinetics and thermodynamics of th e binding of ribo¯avin, ... However,their ability to bind ¯avin is a property that has yet to beexplored in the context of protein folding, and it is like ly thatthey will also prove to be useful a s models for folding of a/bproteins...