Báo cáo y học: "The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes" ppsx

Báo cáo y học: "The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes" ppsx

Báo cáo y học: "The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes" ppsx

... MV, Dinarello CA: Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I. IL-1 receptor antagonist inhibits IL-1- induced cytokine syn- thesis and blocks the binding of IL-1 to its type ... enhanced the production of IL-1Ra by human synovial fibroblasts and articular chondrocytes in the presence of the proinflammatory cytokines IL-1 and TN...
Ngày tải lên : 09/08/2014, 01:23
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Báo cáo y học: "Does switching from oral extended-release methylphenidate to the methylphenidate transdermal system affect health-related quality-of-life and medication satisfaction for children with attention-deficit/hyperactivity disorder&

Báo cáo y học: "Does switching from oral extended-release methylphenidate to the methylphenidate transdermal system affect health-related quality-of-life and medication satisfaction for children with attention-deficit/hyperactivity disorder&

... behavior across the day in contrast to endpoint where the majority reported consistency in behavior. Further, at study end- point the majority of caregivers reported that handling changes in their child's ... social interactions since beginning the study medication, and 91.9% were satisfied with the efficacy of the study medi- cation on their child's attentio...
Ngày tải lên : 25/10/2012, 10:06
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Báo cáo y học: " Laugh Yourself into a Healthier Person: A Cross Cultural Analysis of the Effects of Varying Levels of Laughter on Health"

Báo cáo y học: " Laugh Yourself into a Healthier Person: A Cross Cultural Analysis of the Effects of Varying Levels of Laughter on Health"

... history can be obtained by asking the indi- vidual “how many times do you laugh during your regular day?” and have the individual rate their level on a scale of one to ten. Furthermore, other ... hepatobiliary system, genitourinary system, reproductive system, CNS and psychiatric conditions, and then to specify the name of that con- dition. If the participant failed to i...
Ngày tải lên : 26/10/2012, 09:57
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Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"

Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"

... domains or by specific phosphopeptides that bind to the SH2 domains. The tandem SH2 domains bind to Tyr-627 and Tyr-659 simultaneously in a specific orientation, in which Tyr-627 binds to the ... diagnosis of cancer. In summary, the Gab1 A/A was associated with the low risk of H. pylori infection while the G/A and A/A genotypes together may increase the risk fo...
Ngày tải lên : 31/10/2012, 15:37
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Báo cáo Y học: Baboon cytochrome P450 17a-hydroxylase/17,20-lyase (CYP17) Characterization of the adrenal microsomal and cloned enzymes docx

Báo cáo Y học: Baboon cytochrome P450 17a-hydroxylase/17,20-lyase (CYP17) Characterization of the adrenal microsomal and cloned enzymes docx

... cytochromes P450 has identified domains in the primary sequence of human CYP17 which are involved in the catalytic activity of the enzyme, i.e. substrate docking and binding, the active site including ... formation of 16a-hydroxyprogesterone. Both expressed enzymes had no lyase activity towards PROG or 17-OHPROG. Understanding of the complexity of hydroxylase and...
Ngày tải lên : 08/03/2014, 09:20
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Báo cáo Y học: An active site homology model of phenylalanine ammonia-lyase from Petroselinum crispum docx

Báo cáo Y học: An active site homology model of phenylalanine ammonia-lyase from Petroselinum crispum docx

... amino acids in the chain A of the model, 43 were outside of the likely Phi/Psi combinations in the Ramachandran plot (including Gly and Pro). Most of the deviations were found in the 64–531 and ... play a role in binding the carboxylate moiety of the substrate, whereas residues Y1 10 and N260 can interact with amine/ammonia in the substrate and pro...
Ngày tải lên : 08/03/2014, 23:20
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Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-specific protein over-expressed in Escherichia coli pptx

Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-specific protein over-expressed in Escherichia coli pptx

... protein quality between Pfg27 A and the rest of the constructs was retained. Therefore, the differing protein solubilities were inherent in the constructs and could not be modulated by varying the ... proteins were expressed and purified. Our results show that the fusion proteins were labile and only partially soluble in five of the constructs resulting in very p...
Ngày tải lên : 23/03/2014, 21:20
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Báo cáo Y học: Potential active-site residues in polyneuridine aldehyde esterase, a central enzyme of indole alkaloid biosynthesis, by modelling and site-directed mutagenesis ppt

Báo cáo Y học: Potential active-site residues in polyneuridine aldehyde esterase, a central enzyme of indole alkaloid biosynthesis, by modelling and site-directed mutagenesis ppt

... After determination of the enzyme activity with the standard enzyme assay, the kinetic studies (K m , k cat ) were completed for the active muteins and for the wild-type enzyme. Enzyme and protein assays Protein ... biosynthetic chain starting from tryptamine and secologanin and cata- lyses the conversion of polyneuridine aldehyde into the next stable pathway inter...
Ngày tải lên : 24/03/2014, 04:21
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Báo cáo Y học: Amphibian peptides that inhibit neuronal nitric oxide synthase The isolation of lesueurin from the skin secretion of the Australian Stony Creek Frog Litoria lesueuri docx

Báo cáo Y học: Amphibian peptides that inhibit neuronal nitric oxide synthase The isolation of lesueurin from the skin secretion of the Australian Stony Creek Frog Litoria lesueuri docx

... with Ca 2+ calmodulin, they should also inhibit the activity of calcineurin. The four model peptides lesueurin, citropin 1.1, frenatin 3 and caerin 1. 9, all inhibit the activity of calcineu- rin, but at ... the presence of increasing concentrations of Ca 2+ calmodulin, the inhibition dropped by  50% in each case. In addition, these peptides also inhibit the activit...
Ngày tải lên : 31/03/2014, 15:20
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Báo cáo y học: "Hereditary angioedema: beyond international consensus - circa December 2010 - The Canadian Society of Allergy and Clinical Immunology Dr. David McCourtie Lecture" pps

Báo cáo y học: "Hereditary angioedema: beyond international consensus - circa December 2010 - The Canadian Society of Allergy and Clinical Immunology Dr. David McCourtie Lecture" pps

... pub- lished in HAE prophylaxis and therapy and these have led to the licensing of pdC1INH (Berinert ® ,CSLBehr- ing; Cinryze ® , ViroP harma; Ceto r-n ® , Sanquin) in many parts of the world; bradykinin ... C1 INHIBITOR (C1INH) If “failing” on demand therapy with any of the angioedema event therapies (AERx’s; pdC1INH, rhC1INH, bradykinin B2 receptor antagonist, k...
Ngày tải lên : 08/08/2014, 21:20
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