... Spain. Throughout the follow-up of theEMECAR cohort, the percentage of patients without anyDMARD declined while the frequency of patients on combinedtherapy increased. In addition, combination ... [http://www.ser.es/practicaClinica/Guias_Practica_Clinica.php].21. Godinho F, Godfrin B, El Mahou S, Navaux F, Zabraniecki L, Can-tagrel A: Safety of leflunomide plus infliximab combinationtherapy in rheumatoid arthritis. ... der, Linden Svan der: COBRA combination therapy in patients with early rheumatoid arthritis: long-term structural benefits of a briefintervention. Arthritis Rheum 2002, 46:347-356.15. Young...