... Treatment of rheumatoid arthritis with methotrexate and hydroxychloro-quine, methotrexate and sulfasalazine, or a combination of the three medications: results of a two-year, randomized,double-blind, ... substantially tothe predictability of these results. In the present study we only studied abstracts for onemeeting in one medical specialty, and we classified studiesusing only information available in ... ability to cull weak drugs early in theapproval process (and this frequently occurs), thusexposing fewer patients, improving efficiency in drugdevelopment, possibly reducing the cost of pharma-ceuticals...