Báo cáo y học: "Decreased effector memory CD45RA+CD62L– CD8+ T cells and increased central memory CD45RA–CD62L+ CD8+ T cells in peripheral blood of rheumatoid arthritis patients" ppt
... suggested, the precise
nature of their involvement is not fully understood. In the
present study we examined the central and effector memory
phenotypes of CD4
+
and CD8
+
T cells in the peripheral ... phenotype,
and the significance was not known at that time.
Our finding that peripheral blood CD8
+
T cells exhibit
increased central memory phenotype an...
... method in
order to determine the sensitivity, specificity and accuracy of
MRI, US and radiography in detecting bone erosions in RA
MCP joints.
Materials and methods
Patients and control individuals
Seventeen ... directly transferable to other patient
cohorts. The moderate sensitivity of MRI found in this study
suggests that the applied OMERACT RAMRIS definition of
erosio...
... Kawashima M, Taniai M, Yamauchi H, Tanimoto T,
Kurimoto M, Morita Y, Ohmoto Y, Makino H: Interferon-gamma-
inducing activity of interleukin-18 in the joint with rheumatoid
arthritis. Arthritis Rheum ... : Th1 cytokine balance in blood, was higher in RA
patients. These findings suggest that in RA the Th1 : Th2
ratio in the blood and that in the synovium are differen...
... in the
CSF of SLE patients with and without CNS involvement,
and to assess these data prospectively with respect to
immunosuppressive treatment. Our results indicate that
the SLE patients studied ... brain pathology. This
finding, together with increased intrathecal levels of
TGF-β, indicates an ongoing destructive parenchymatous
process in the SLE brain.
In addition, the pres...
... possibility is that OA chondrocytes may be
less sensitive to loading response. Lastly, other inflammatory
factors may act on chondrocytes mainly as stimuli hiding the
load effect. This loss of regulation ... to type II
collagen found in the matrix cartilage areas according to load-
bearing capacity suggest that the balance between the major
structural proteins seems to be crucial to the i...
... were detected in SFs of 77 of the 81
RA patients and in plasmas of 19 of the 78 patients by immu-
noblotting (Figure 4a). In addition, very low concentrations of
actin were detected in 2 of the ... space
or other affected organs in order to maintain a steady-state
concentration at the site of inflammation. pGSN has the poten-
tial to interact with several macromolecu...
... that presents later [8-10].
Immunity to mycobacterial infections is influenced by the
counteracting effects of effector cytokines and regulatory
cytokines, such as interleukin (IL)-10, in patients ... Ottenhoff TH: Dynamic changes in pro- and anti-
inflammatory cytokine profiles and gamma interferon
receptor signaling integrity correlate with tuberculosis dis-
ease activity and...
... conceived of the study and
participated in its design and coordination. All authors read and approved
the final manuscript.
Competing interests
The authors declare that they have no competing interests.
Received: ... at initia-
tion of resuscitation continues in the international com-
munity. The present study focused on understanding
the alterations in GABA content, total GAB...
... catalytically active, both in vitro
and in vivo. The activity of MMPs is increased by gene
transcription, extracellular activation of the secreted
inactive zymogen form, and reduced activity of ... needle inserted into the inter-
nal carotid artery distal to the stenotic lesion. A shunt
was not considered necessary in any case. After
clamping the internal carotid artery,...
... results obtained indicate
co-immunoprecipitation and, therefore, interaction between
Fig. 1. Effect of SRF co-expression on the activity of CArG-containing promoters. (A) Activity of CArG-containing ... given to each construct is indicated to the right (N1 to N7, C1
and M). Numbers to the left indicate the N-terminal amino acid encoded by each construct. Constructs C1 and M terminat...