... alter pain sensitivity at the periphery. Theseunderlying central mechanisms of FM are likely to be reflected in altered supraspinal processing and may originate, in part,at supraspinal sites.The ... sensory fibers are composed of two types: thinly myelinated Aδ fibers andunmyelinated C fibers. Aδ fibers are rapidly conducting andtransmit signals that produce perceptions of relatively sharp,incapacitating ... mostcommonly activated brain regions for pain in healthy subjectswere SI, SII, IC, ACC, PFC and thalamus [18]. Interestingly,simply the anticipation of pain activates similar regions (PFC,anterior insula,...