... order to better understand the folding mechanismin the presence of RCGred⁄ RCGox, the folding inter-mediates were further analyzed in detail. The disul de pairing of prouroguanylin was determined ... disul de pairing, with two thiolsand two disul de bonds, with three disul de bonds and no thiol groups, and the fullyreduced form of prouroguanylin, respec-tively.Acceleration of disul de- coupled ... except for the cysteine residue, in the disul de- coupled folding reactions is not known in detail. Inthis study, to investigate the role of each amino acidresidue of glutathione, a series...