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Báo cáo y học: "Mourning and melancholia revisited: correspondences between principles of Freudian metapsychology and empirical findings in neuropsychiatry" pptx

Báo cáo y học:

Báo cáo y học: "Mourning and melancholia revisited: correspondences between principles of Freudian metapsychology and empirical findings in neuropsychiatry" pptx

... purposes)Annals of General PsychiatryOpen AccessReviewMourning and melancholia revisited: correspondences between principles of Freudian metapsychology and empirical findings in neuropsychiatryRobin ... sorelentlessly and so unjustifiably' [76].Neuropsychiatric findings in depression correlated with principles of Freudian metapsychology HypofrontalityOne of the most consistent findings in the ... consist-encies between Freudian metapsychology and recent find-ings in neuropsychiatry, especially those relating todepression. A case will be made that findings in neuroim-aging and neurophysiology can...
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Báo cáo Y học: Propionate CoA-transferase from Clostridium propionicum Cloning of the gene and identi®cation of glutamate 324 at the active site pdf

Báo cáo Y học: Propionate CoA-transferase from Clostridium propionicum Cloning of the gene and identi®cation of glutamate 324 at the active site pdf

... puri®ed and the gene encoding the enzyme has beencloned and sequenced. The enzyme was rapidly and irre-versibly inactivated by sodium borohydride o r h ydroxyl-amine in the presence of propionyl-CoA. ... differences of )14 Da and +15 Da forsodium borohydri de and hydroxylamine inactivatedenzyme, r espectively. In particular the observation of achymotryptic peptide comprising amino acids 322±338 ... loss in activity. Thepurity of the enzyme was con®rmed by SDS/PAGE withCoomassie-staining of the proteins and by RP-HPLCfollowed by mass spectrometry [14].Fig. 1. The fermentation o f alanine...
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Báo cáo y học:

Báo cáo y học: "Primary lower limb lymphedema: a focus on its functional, social and emotional impac"

... I Anyfantakis, Christos Lionis Clinic of Social and Family Medicine, Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece.  Corresponding ... inability of the lymphatic system to maintain normal tissue homeostasis [1]. It may be classified as primary or secondary [1]. Primary lymphedema re-sults from congenital abnormality or dysfunction ... found interesting to review known cases of lymphe-dema in the island of Crete. These reports f ocu s on two cases of primary lower limb lymphedema, by discussing the overall physical and mental...
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Tài liệu Báo cáo Y học: Convulxin induces platelet shape change through myosin light chain kinase and Rho kinase ppt

Tài liệu Báo cáo Y học: Convulxin induces platelet shape change through myosin light chain kinase and Rho kinase ppt

... rearrangements, by inhibiting actinassembly and focal adhesion in many cell types [8,9] throughthe decreased phosphorylation of various proteins [10,11]including MLC [12]. In a previous study of our ... receptor c-chain, leading totyrosine phosphorylation and activation of syk and PLCc2[13,14]. Following activation of GpVI by convulxin, severaladapter molecules are tyrosine phosphorylated and/ orrecruited ... doi:10.1046/j.1432-1033.2002.03305.xsubstratum in many cell types [9,29]. Protein kinase A, onceactivated, phosphorylates myosin light chain kinase(MLCK), thus inhibiting its activity and causing a decrease in MLC phosphorylation...
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Báo cáo Y học: A novel DNA repair enzyme containing RNA recognition, G-patch and specific splicing factor 45-like motifs in the protozoan parasite Toxoplasma gondii potx

Báo cáo Y học: A novel DNA repair enzyme containing RNA recognition, G-patch and specific splicing factor 45-like motifs in the protozoan parasite Toxoplasma gondii potx

... reactivation of encysted bradyzoites into activelyreplicating and cytolytic tachyzoites can trigger a diseasewith severe clinical syndromes leading in many cases to thedeath of the patients. ... tachyzoites differentiate intoencysted bradyzoites in response to the immune systemattack during disease progression. They will remain in thebrain and other organs during the lifetime of infected ... also found in a variety of RNA binding proteins, including heterogeneous nuclearribonucleoproteins (hnRNPs), proteins implicated in regu-lation of alternative splicing, and components of smallnuclear...
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Báo cáo Y học: A Ca2+/CaM-dependent kinase from pea is stress regulated and in vitro phosphorylates a protein that binds to AtCaM5 promoter ppt

Báo cáo Y học: A Ca2+/CaM-dependent kinase from pea is stress regulated and in vitro phosphorylates a protein that binds to AtCaM5 promoter ppt

... effect of phosphorylation on its DNA-binding property was tested. The protein was in vitrophosphorylated using cold ATP and used for DNA bindingstudies. No binding was detected when prephosphorylatedprotein ... regulated in response to multiplestresses and probably has a role at the very beginning of multiple stress signaling pathways [37]. Involvement of CDPKs in stress signaling has also been shown byusing ... some protein kinases are involved in stress signaling pathways [29] and recent work pointstowards the involvement of Ca2+/CaM-dependent proteinkinases in stress signaling [16], changes in the...
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Báo cáo Y học: Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant doc

Báo cáo Y học: Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant doc

... Efavirenz.Furthermore, wing2 composed of the heterocyclic ringstructure of MSC194 and the substituted pyrimidinefunctionality of PNU142721 occupy the same part of theNNIBP as the benzoaxine-2-one ring of Efavirenz. ... the binding modes of the three inhibitors aresuperimposed in the mutant NNIBP. The cyclopropyl-group of MSC194 and the methyl group of PNU142721partly overlap the trifluoromethyl group of Efavirenz.Furthermore, ... Efavirenz. In asimilar manner, the position of wing1 composed of thesubstituted phenyl ring of MSC194 and the fused ring-structure of PNU142721 overlap the less bulky cyclopropylgroup of Efavirenz.The...
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Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-specific protein over-expressed in Escherichia coli pptx

Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-specific protein over-expressed in Escherichia coli pptx

... solubility of fusion proteins is not necessarily indicative of either properfolding or of increased solubility of the protein of interest.We propose that the success of fusion protein systemsshould ... Hopkins UniversityBloomberg School of Public Health, Baltimore, Maryland, USAThe presence of extra N- and C- terminal residues can play amajor role in the stability, solubility and yield of ... soluble in five of the constructsresulting in very poor yields. Intriguingly, in the sixth con-struct, the yield of soluble fusion protein with an extendedcarboxyl terminus of 17 residues was...
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Báo cáo Y học: A new conceptual framework for enzyme catalysis Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes docx

Báo cáo Y học: A new conceptual framework for enzyme catalysis Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes docx

... thisunderstanding is gained, H-tunneling can then be used asa tool for (a) increasing the catalytic efficiency of enzymes in the biotechnology industry (by enhancing the coupling of dynamics to ... and flavoprotein enzymes that catalyse the oxidation of anumber of amine substrates, and computational studies of enzymic H-tunneling in these enzymes.QUINOPROTEIN AND FLAVOPROTEINAMINE DEHYDROGENASESThe ... Scrutton1Departments of 1Biochemistry and 2Chemistry, University of Leicester, UKRecent years have witnessed high levels of activity in iden-tifying enzyme systems that catalyse H-transfer by quantumtunneling....
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Báo cáo y học:

Báo cáo y học: "Is Obesity Associated with an Increased Risk for Airway Hyperresponsiveness and Development of Asthma" pdf

... Section of Respirology, Department of Internal Medicine; Richard Warrington: Section of Allergy and Immunology, Department of Internal Medicine; and Mary Cheang:Department of Community Health ... control of cytokine production.38Thehormone leptin of the IL-6 family has effects oninflammation, including the release of IL-6 from macro-phages and lymphocytes.39,40Leptin levels in adulthoodare ... to increase during exercise.27Thus, waning FRC and tidal volumes may result in alterations in the airwaysmooth muscles and hence increased airways resistance and methacholine reactivity. Therefore,...
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