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Báo cáo y học: "How safe are the biologicals in treating asthma and rhinitis" doc

Báo cáo y học:

Báo cáo y học: "How safe are the biologicals in treating asthma and rhinitis" doc

... Interleukin-13 InhibitionInterleukin-4 (IL-4) and Interleukin-13 (IL-13) are cytokines that play a role in allergic inflammation byinducing Th2 responses. Interleukin-4Rα is the signalingcomponent of the ... authorsconcluded that there may be an increased risk of anaphy-laxis in asthmatic patients that may be dependent on the severity of asthma. Another variable and difficulty in interpreting the safety ofbiologics ... purposes)Allergy, Asthma & Clinical ImmunologyOpen AccessReviewHow safe are the biologicals in treating asthma and rhinitis?Linda S CoxAddress: Department of Medicine, Nova Southeastern University...
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Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc

Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc

... (1994)Dioxygen-induced decarboxylation and hydroxylation of[NiII(glycyl-glycyl-L-histidine)] occurs via NiIII: X-ray crystalstructure o f [NiII(glycyl-glycyl-a-hydroxy-D,L-histamine)]3H2O.J. ... modelling of C u(II) and Ni(II)transport by albumins. On the other hand, the directthermodynamic and kinetic characterization of Ni(II)binding at site I in HSA and BSA was obtained. Thesedata ... (1979) So lid phase synthesiswithout repetitive hydrolysis. Preparation o f leucylalanyl-glycyl-valine using 9-fluorenylmethyloxy- carbonylamino acids. Int.J. Peptide Protein Res. 13, 35–42.27....
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Báo cáo y học:

Báo cáo y học: "How possible is the development of an operational psychometric method to assess the presence of the 5-HTTLPR s allele? Equivocal preliminary findings" pdf

... data and writing the paper. AL participated in the genetic and statistical analysis. HSAparticipated in designing the study, analysing the data and writing the paper. GB participated in designing ... designing the study, analysing the data and writing the paper. All authors read and approved the finalmanuscript.Competing interests The authors declare that they have no competing interests.Received: ... participated in the statistical analysis and wrote the paper.KNF conceived the study, carried out the literature search and analysis and participated in writing the paper. ZR participated in analysing the...
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Tài liệu Báo cáo Y học: Transactivation domains are not functionally conserved between vertebrate and invertebrate serum response factors potx

Tài liệu Báo cáo Y học: Transactivation domains are not functionally conserved between vertebrate and invertebrate serum response factors potx

... contained the cDNA region coding for the N-terminal and MADS-box domain from one species and the region coding for the C-terminal domain from another species. Hybrid moleculeswere cloned in the ... extracts were analyzed by Western blotting using an antimycantibody. The migration of the fusion proteins containing the myc epitope: human (HsSRF-myc), D. melanogaster (DmSRF-myc) and A. fran-ciscana ... [10,11].SRF binding sites found in the promoter of serum-induced and muscle-specific genes are very similar and containconsensus CArG boxes: CC(A/T)6GG [12]. Despite the similarity in their SRF-binding...
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Báo cáo toán học:

Báo cáo toán học: " Permutations which are the union of an increasing and a decreasing subsequence" doc

... green since R G and R and G are the maximal red and green points under “ ”. Thus at least one of them, P say is yellow. Since the yellow points are decreasing and Y is the smallest yellow point ... meaning; for example, if R and W are red and white points wewould have R W and W<R. Furthermore, the green and blue points are increasing, the red and yellow points are decreasing, and the ... white points are either increasing or decreasing. In proving this theorem we shall use only the property of skew-merged per-mutations that they avoid 3412 and 2143; in our ‘point’ terminology thismeans...
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Báo cáo y học:

Báo cáo y học: "Critical Aspects of the History of Occupational Asthma" pdf

... irritant-induced occupational asthma. Although such features of the history are sensitive indicators of occupational asthma, they are not specific and should therefore be followed by fur-ther investigations ... productsused by the patient and by co-workers in the areacan assist in obtaining these. However, MSDSs are designed to list toxic effects rather than hyper-sensitivity responses and may not list “natural ... removalfrom further exposure to the sensitizer, especiallyearly after the onset of symptoms and when the asthma is relatively mild.5Nevertheless, the diag-nosis can result in very significant...
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Báo cáo y học:

Báo cáo y học: " Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue infections" pdf

... ofinducing synthesis of inflammatory cytokines such as IL-1β and TNF-α from host cells [13]. Whether the MMP induction in fibroblasts by S. aureus component(s) is due to the cytokine/chemokine ... osteomyelitis in murine models of these diseases. Wetherefore tested the ability of cell lysates and culture superna-tants obtained from these mutants and their isogenic parentstrain to induce ... agents for 30 min-utes before assaying for tyrosine phosphorylation. The assays were car-ried out in triplicate. There was significant increase in tyrosine phosphorylation in S. aureus culture...
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Báo cáo y học:

Báo cáo y học: " Review Cells of the synovium in rheumatoid arthritis" ppsx

... directedtoward the nuclear antigen RA-33 and heavy chain bindingprotein, both of which are found in early RA and pre-diseasesera [29]. Antibody and T-cell reponses to heavy chain bindingprotein have ... be involved in the induction and maintenance of the proinflammatory cytokine cascade.Role played by B cells as antigen-presentingcells in rheumatoid arthritisB cells actively participate in ... approachthan targeting a single cytokine or chemokine. The role played by B cells in the maintenance of ectopicgerminal centre-like structures, as well as in the immuneresponse in RA synovium, has...
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Báo cáo y học:

Báo cáo y học: " Review Cells of the synovium in rheumatoid arthritis" pot

... probably including the synovium [8,11].Furthermore DC, along with synoviocytes and macrophages,produce innate immune inflammatory mediators, and thesemediators drive inflammatory pathology in ... unchargedcarbonyl group, increasing the affinity of citrullinated proteinswith the shared epitope. Fibrin and vimentin are two citrulli-nated proteins identified thus far in synovial extracts frominflamed ... TLR9Major cytokines produced IL-12 IFN-αProduce proinflammatory and anti-inflammatory cytokines and chemokines in response to a variety of signalsTissue location Epithelium and epithelial Nonepithelial...
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Báo cáo y học:

Báo cáo y học: "Review Cells of the synovium in rheumatoid arthritis" pot

... cellularinteractions in the RA joint involving macrophages, T and Blymphocytes, and synovial fibroblasts. Laboratory investi-gations in vitro and in vivo have resulted in new findingsabout the role of the ... haveprimary roles in the inflammatory and catabolic processes in the joint, they may also promote cartilage damage, directly orindirectly. Despite the clinical success of anti-TNF therapy forRA, there ... in the inflamed synovium as a result of the influxof inflammatory cells from the circulation and synovial cell hyperplasia. The upregulation of proinflammatory cytokines produced primarily in...
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