... During the delayed phase, brain angiogenesis may pro-vide the critical neurovascular substrates for neuronal remodeling. In thisminireview, we propose the hypothesis that the biphasic nature of ... Over the course of hours todays, the penumbra collapses if therapy is not initiated in time. Besides neuronal death per se, collapse of the acute penumbra can also be viewed in terms of the degradation ... remodeling remains to be determined,but given the emphasis on targeting JNK in acutestroke, these types of biphasic repair responses deserveconsideration. An untitrated wholesale inhibition of JNK...