... function of TRAIL containing the extracellular domain (amino acids 114–281) of the human liver cancer cell line, QGY-7703 [27], we treated the cells with increasing concentrations of TRAIL and thenanalysed ... the activation of caspases, such as procaspase-9 and caspase-3,by binding to the inhibitor of apoptosis proteins and thusdisrupts linkage of the caspase–inhibitor of apoptosisproteins complex during ... targetgenes of p53 include p21, Bax, DR4, DR5, DcRs and Bcl-2.Upregulation of p53, resulting in the enhanced expression of DR4 and/ or DR5 in some cancer cell lines, is believed to beone of the mechanisms...