... IL-10-producing regulatory B cells (Bregs),regulatory DCs and suppressive macrophages on the onehand, and pro-inflammatory effector lymphocytes and monocyte-derived cells on the other, is likely to dictate ... anti-inflammatorycytokines released by Tregs, such as IL-10 and TGFβ, isantagonised by the myriad pro-inflammatory factors present inthe synovia. Perfusion of Tregs is unlikely to provide a longstanding ... Ferguson PJ,Whitesell L, Kelly TE, Saulsbury FT, Chance PF, Ochs HD: Theimmune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. NatGenet...