... infectivity of HIV and also have anti -in ammatory activity. Since 2006, several patients carry-ing a fusion protein, originating from a translocation joining genes encodingthe kinases ITK and spleen ... that the combined inactivation of BTK and TEC in mice causes a phenotype resembling XLA,thus delineating species-specific redundancy. The R28Cmutation, which abolishes binding to activation-induced ... secondary to the strong in uence of prolineson peptide folding [21]. Thus, proline is a rigid aminoacid creating a fixed kink in a protein chain.Similar to the situation in many other genes, CpGdinucleotides...