... (*), (**) and (***), P < 0.05, 0.01 and 0.001 versus hypoxia. [*] and [**], P < 0.05 and 0.01 versus PMA alone. (E) The table sum-marizes the inhibition percentage of HIF-1, c-myc and AP-1 ... and transcriptional activity. In this work, it is shown thatechinomycin strongly inhibits the activity of HIF-1 under hypoxic condi-tions, and also interferes with the activity of other transcription ... (2000) The expression and distribution of the hypoxia-inducible factorsHIF-1alpha and HIF-2alpha in normal human tissues,cancers, and tumor-associated macrophages. Am JPathol 157, 41 1–4 21.7...