... storage form of the cofactor in some organisms (e.g. riboflavin-bindingprotein in chicken eggs and dodecin in archaeons[41,42]). In addition, organisms (e.g. mammals) lackingvitamin B2biosynthesis ... 3, FMN and FAD bindingare vastly different with respect to the topology of thebinding pocket, indicating that the adenosine moietystrongly affects the mode of cofactor binding. The pre-ferred ... group of a cysteine) of theisoalloxazine ring [44], or, in one case, it is bicovalentlylinked to N1 of a histidine and the thiol group of acysteine [45]. Only recently, a novel attachment of FMN...