Báo cáo khoa học: "Localization of antigenic sites at the amino-terminus of rinderpest virus N protein using deleted N mutants and monoclonal antibody" doc

Báo cáo khoa học: Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (AriceptÒ) to cholinesterases doc

... class of inhibitors haveindicated that both the benzoyl containing functionality and the N- benzylpiperidine moiety are the key features forbinding and inhibition of AChE. In the present study, the interaction ... performed on a series of indanone-benzylpiperidines synthesized by Eisai. Thesestudies elucidated the effect of substitutions on the benzyl and indanone rings of this class of inhibitors on theirinhibition ... substrate concentration range of 0.01–30 mM and at least six inhibitor concentrations to determine the components of competitive and noncompetitive inhibi-tion. For each enzyme, the measurements...

Tài liệu Báo cáo khoa học: A systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsis thaliana doc

... is indispensable.Integration of data on, for example, gene expression, protein abundance, metabolite concentration and otherbiological parameters with an iterative model, and exploration of ... arereversibly interconnected. The rate of sucrose export to sink organs (rSuc ﬁ Sinks)was calculated as the difference between the spline-interpo-lated rates of net photosynthesis and of changes in the carbohydrate ... depends on the concentration of the reaction product and the dissociation constant Ki,Bforinhibitor binding. The rate of hexose-based sucrose synthesis was describedby the mass action rate...

Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc

... determination of the toxin concentration) have to be considered.a-Conotoxin SequenceaFunctional DataBinding Data (n M)cIC50 (n M) on recombinant nAChRsbIC50 (n M) in native tissues and suggested ... of a-conotoxins in the determination of the structure and function of native nAChRs, and indicatethat selectivities and potencies found on oocyte-expressednAChRs can be extrapolated to native ... provideduseful information on the binding mode of a-conotoxins[53,58] and the activation states of the nAChR. At the a7[L247] nAChR (a single point mutant that does not showdesensitization), [A10L]PnIA...

Báo cáo khoa học: Neural retina leucine-zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor development pdf

... manner(lanes 4 and 5), whereas the control GST protein alonedid not form DNA protein complexes (lanes 2 and 3). The presence of Nrl in the protein DNA complex wasveriﬁed with antibody against ... blotting.Fig. S1. Expression of neural retina Nrl mRNA.Fig. S2. Generation of the polyclonal antibody for Nrl and expression of Nrl proteins in various cell lines.Fig. S3. Efﬁciency of Nrl siRNA ... mechanisms underlying the transcrip-tional control of PP2A genes and the effects of diversecombinations of PP2A subunits have not yet been elu-cidated.Neural retina leucine-zipper (Nrl) belongs...

Báo cáo khoa học: "Speech Technology: from Research to the Industry of Human-Machine Communication" potx

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Báo cáo khoa học: "A Unified Statistical Model for the Identification of English BaseNP" pptx

... baseNP information.Whether or not the baseNP information canimprove the precision of POS tagging in ourapproach is determined by the identifierassignment of the baseNP rules when trainingtrigram ... RBVBDNNSCDpVBDNNRBpNNVBDpNNp ××Φ×ΦΦ×])[],[|(.])[,|]([ NNNNNNSCDpNNSCDRBNNNNp ××Figure 2: All possible brackets of "stock was down 9.1 points yesterday morning"Figure 3: the transformed ... errordriven pruning approach trained on PennTreebank. It extracts baseNP rules from the training corpus and prune some bad baseNP byincremental training, and then apply the prunedrules to identify...

Báo cáo khoa học: "PARSING VS. TEXT PROCESSING IN THE ANALYSIS OF DICTIONARY DEFINITIONS" pot

... lexical entry, and by including only a few disambignations, just to give the flavor of their presence. Disambignation of a word is indicated by the inclusion of its homograph and sense numbers ... Relation, Word2: (3) funny SYN amusing (4) funny SYN facetious A third relation, particularly important in W7 and in dictionaries generally, is taxonomy, the species-genus relation or (in ... inverted, inflected forms analyzed, and other modifications of the kind often brought under the rubric of "transformations." The LSP can do this sort of thing very welL The defining words...

Báo cáo khoa học: "A Memory-Based Approach to the Treatment of Serial Verb Construction in Combinatory Categorial Grammar" pdf

... ‘make’ as s\np/np and ap-plying the serialization rule in (14). In (16), the derivation can be done by assigning ‘hurry’ and ‘run’ as s\np, and ‘cross’ ass\np/np.Since Chinese and Thai are ... types\np/np is induced on the right conjunct. The co-ordination operation associates the ﬁller and the gap resulting in a complete derivation.A signiﬁcant feature of the memory mechanismis that ... constraint preserves the ordering of combinatory operations.We then transform the functional applicationrules into LIG productions. From Condition A,we can generalize the functional application...

Báo cáo khoa học: Oxidative stress is involved in the permeabilization of the inner membrane of brain mitochondria exposed to hypoxia/reoxygenation and low micromolar Ca2+ Lorenz Schild1 and Georg Reiser2 doc

... inhibitsopening of the mPTP by occupying binding sites located in the inner and outer mitochondrial mem-brane [39,40]. The binding of ADP stabilizes the matrix conformation of the adenine nucleotide ... demonstratethat the reduction of H2O2concentration in the pres-ence of TEMPOL signiﬁcantly protected mitochondriafrom permeabilization of the inner membrane uponH ⁄ R in the presence of ... respiration and oxygen consumptionwas analysed. The corresponding values are shown inFig. 1. After 15 min of incubation in the presence of 3.5 lm Ca2+in an air atmosphere, state 3 respirationof...

Báo cáo khoa học: Glucagon-like peptide-2 stimulates the proliferation of cultured rat astrocytes pptx

... strand cDNA was synthesized at 52 °C for 1 h, and amplification of GLP-2R cDNA wasperformed at an annealing temperature of 65 °Candanextension temperature of 72 °C for 30 cycles. RT reactionswere ... a significant increase in the mRNAs of c-fos and c-junwhen gene expression was determined by Northern blotting.These results suggest that GLP-2 directly stimulates the proliferation of rat astrocytes; ... expressed in a tissue-specific manner,mainly on subsets of enteric nerves [7] and in gut endocrinecells [5,8], and in several regions of the central nervoussystem, including the murine thalamus,...

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