... [12],making a combinatorial approach with vaccination andtrastuzumab an attractive clinical treatment modality.pDNA immunization has several advantages as com-pared to other vaccination strategies; while ... Houghton AN,Bergman PJ: Vaccination with human tyrosinase DNA induces antibodyresponses in dogs with advanced melanoma. Cancer Immun 2006, 6:8.19. Bergman PJ, Camps-Palau MA, McKnight JA, Leibman ... overexpressedin a number of malignancies including breast, o varian,cervical and renal carcinoma [1,2] and represe nts anattractive therapeutic target. Tra stuzumab (Herceptin), a recombinant humanized...