Báo cáo sinh học: " Happy together: genomic insights into the unique Nanoarchaeum/Ignicoccus association" pdf

... including 19 genesotherwise common to all crenarchaeal genomes, have beenlost in the I. hospitalis genome [3]. The authors put forward the hypothesis that these losses may be linked to the adaptation ... significantly smaller thanthat of the average free-living bacteria or archaea [3]. The authors put forward the hypothesis that, as with N. equitans[6,7], the small size of the genome of I. hospitalis ... gone furtherin the smaller N. equitans genome [2], and it has beenproposed that these features are primitive, leading to the hypothesis that this archaeon is a living fossil [8]. To us, the fact...

Báo cáo khoa học: Structural and thermodynamic insights into the binding mode of ﬁve novel inhibitors of lumazine synthase from Mycobacterium tuberculosis pptx

... if the ribityl chain in the otherstructures. The distance between the pyrimidine ringand the phosphate atom in the phosphate moiety is6.9 A˚. The location of this group is the same as in the structures ... binding isotherms for the inhibitors (F). The ﬁlled circles in the binding isothermsrepresent the experimental values of the heat change at each injection; the continu-ous lines represent the results ... the smaller size of the pyrimidine ring. It has in addition resulted in the slightdeviation from their parallel ring positions. The shiftedposition of the pyrimidine system, together with the small...

Báo cáo sinh học: " In vivo transcriptional targeting into the retinal vasculature using recombinant baculovirus carrying the human flt-1 promoter" potx

... autocrine-paracrine effect or into the blood-stream for a systemic effect. Within the vasculature,endothelial cells are the main target for gene therapybecause they are closely related with ... endothelial-specific gene expres-sion [16]. So far, there is no information available con-cerning the use of endothelial-specific promoters in the context of the baculovirus genome. Furthermore, ... together, our results indicate that the restricted expression in endothelial cellsmediated by the flt-1 promoter is not affected by the context of the baculovirus genome anddemonstrate the...

Báo cáo sinh học: "Colugos: obscure mammals glide into the evolutionary limeligh" ppt

... in that the patagium also extends between the hind limbs and the short tail, even stretching between fingers and toes (hence the name ‘mitten-gliders’). The lower incisors are unique: the forward-leaning ... al.[8] thus provide more evidence for the hypothesis thatScandentia and Dermoptera have a closer phylogeneticrelationship to each other than either of them has toPrimates. This is confirmation ... (patagium)surrounding almost the entire body margin. Colugos arealso called ‘flying lemurs’, but - as Simpson aptly noted [1] -they “are not lemurs and cannot fly”. They differ from othergliding mammals...

Báo cáo sinh học: "Mechanisms of ubiquitin transfer by the anaphase-promoting complex" pdf

... hydrolysis to the formation of a thioester bond between the active-site cysteine of the E1 and the carboxyl terminus of ubiquitin. The E1 then transfers the activated ubiquitin to the active-site ... Finally, the E3, or ubiquitin-protein ligase (green), facilitates the transfer of the ubiquitin from the E2 to a lysine on the target protein (substrate, magenta). In the case of the APC and many other ... surfaces on the APC core. The two APC subcomplexes are held together by the largest APC subunit, Apc1 (Figure 4). Apc4 and Apc5 help connect Apc1 to the base of the TPR subcomplex, Cdc23. The non...

Báo cáo sinh học: "A functional genomic analysis of cell morphology using RNA interference" pptx

... phenotypes in the one celltype (but were detected in the other). The set included all 160 genesidentified by an RNAi phenotype in each of either S2R+(gray) or Kc167(black) cell types. (b) The percentage ... functional genomic analysis ofanimal cell form. The availability of well-annotatedDrosophila genomic sequence simplifies the design of gene-specific double-stranded RNAs (dsRNAs) [4]. Furthermore, the ... targets the destruction of endogenous mRNA, the efficacy of RNAi and thus the phenotypic strength couldreflect gene- and cell-type-specific differences in mRNAlevels, the levels and stability of the...

Báo cáo khoa học: Structural and functional insights into Erwinia carotovora L-asparaginase ppt

... 5¢-CCTCTCGAGATAAGCGTGGAAGTAATCC-3¢. The NdeI and XhoI sites (underlined) were intro-duced at the 5¢-terminus and the 3¢-terminus, respectively,of the EwA gene for cloning into the pET22b vector(Novagen). The resulting ... their therapeutic inefﬁciency[18]. In most of the studies, the catalytic properties of the enzymes were characterized in detail, but otherimportant parameters, such as oligomerization andthermal ... Furthermore, the presence ofl-Asp increased the stability of both asparaginases withrespect to the denaturing effect of temperature andurea, in agreement with the structural analysis of the tetramer....

báo cáo sinh học:" Non-European Union doctors in the National Health Service: why, when and how do they come to the United Kingdom of Great Britain and Northern Ireland?" pdf

... year in the UK amounted to 11.2% (Figure 2).Of the respondents, 88.9% had held a paid NHS post,while the remaining 11.1% had been unemployedthroughout their stay in the UK. Of all the respondents,12.9% ... 2002(11.2%), but thereafter a drop, with 7.7% qualifying in2003, 4% in 2004 and 0.9% in 2005 (Figure 1). The respondents were asked to report the duration of timethey had spent in the UK. Twenty ... doctors working for the National Health System (NHS) of the United Kingdom of Great Britain and Northern Ireland (UK) have obtained their primaryqualifications from a country outside the European Union....

báo cáo sinh học:" Human resources for health at the district level in Indonesia: the smoke and mirrors of decentralization" ppt

... zero. Further, the salariesfor all PNS is the first charge against the so-called uncon-ditional grant from the central government, further reduc-ing their overall decision space on the sector ... clinics. As the health centre was developed, the public treatment clinics were incorporated into the health centres, with the result that only the private balai pengobatan remained. Although they ... somethingthat the current government has been unable to do. When the new vision is there, then the questions of how toensure that there are health care providers and facilities ofquality in the best...

báo cáo sinh học:" Conditions underpinning success in joint service-education workforce planning" pdf

... relationto the short-sightedness of a focus on skills in the absenceof measures that demonstrate the long-term value of pop-ulation-based health care.ConclusionOn the basis of the work we do together ... regardless of the suitability of the programme to the student's needs or abilities [7]. Remain-ing separate from the collaborative planning exercisesdescribed above, these businesses have the potential ... group with as much urgency as the other feels theyshould. These challenges are mirrored in the fact that edu-cators in our system hold line accountability to the Minis-try of Advanced Education...

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