... ciprofloxacin). All concentrations in the placebo calveswere below the limit of detection (4.6 ng/mL). Maximalplasma concentration (Cmax), elimination rate constant(ke) and elimination half-life (T1/2e) ... counting colony-forming units (CFU) distrib-uted over each drop zone and averaged for duplicates. Thespecies identification of one P. multocida colony per ani-mal per day was confirmed by means ... buff-ered saline for 10 s. Plasma samples obtained by centrifu-gation of blood at 4 × g for 10 min were taken on D0 at 0,2, 4, 6, 12, 24 h, on D1 at 48 h, on D2 at 72 h, on D3 at96 h, and on...