... ithERK1/2, VEGF165induced stronger phosphorylation ofMEK1/2 (100%) than did VEGF121(50%) (Fig. 5A,B).MEK1/2 phosphorylation induced by VEGF165andVEGF121was strongly inhibited in the presence ... activation,without affecting the FGF2-induced phosphatidylinositol3-kinase activation [17]. These results strongly suggest thatPF-4 inhibits FGF2-induced end othelial cell proliferationvia an intracellular ... presence of PF-4(10 lgÆmL)1), the phosphorylation of ERK induced byVEGF165and VEGF121was s trongly inh ibited, onlyreaching 18% and 1 % of maximum stimulation, respect-ively (VEGF165alone:...