... shown)[33,34]. In contrast, its similarity to type III PKSs, whichlack this domain, is scant. This domain promotes the binding of the acyl-CoA initiation unit to the ketosynthetasedomain of the PKSs ... 2002 Aminonucleoside A201A biosynthetic genes (Eur. J. Biochem. 269) 5533In actinomycetes, it is well established that genes impli-cated in antibiotic biosynthesis, including those encodingself-resistance, ... This findingsuggests that, similarly to the pur cluster, next to this ORFthere should be additional genes encoding other proteinsimplicated in the biosynthesis of the aminonucleoside moietyof...