... sense of humour: the informationdemands in genomicsarestaggering. The genomecontainstwokinds of digitalinformation,onethatencodes the proteinandRNA‘molecularmachines of life’,and the otherbeing the regulatorynetworksthatspecifyhowthesegenesareexpressed in time,spaceandamplitude.DNAinformationislayeredandarranged in ahierarchy,startingwith the gene,then the RNA, then the protein, then the protein interactions, then the proteincomplexes,then the networks of proteincomplexes in a cell,then the tissues andorgans,then the individualorganism,followedbypopulationsand the ecosystems in whichtheylive. In thiskind of discoveryscience,masteringsuchvastquantities of informationtoanswerimportantquestionsisaskillandanart.And the hardware? The firstautomatedsequencingmachinetookaday, in 1986,tosequence250 of the threebillionbasepairs.Ittook the humangenomeprojecttenyearstosequence the humangenome,twoyearsshorterthanpredicted;and the privatecompanyCelerawithitsso-calledshotgunapproachtooklessthan the publicconsortium’s ... SydneyBrenner’slovely,dolorous sense of humour: the informationdemands in genomicsarestaggering. The genomecontainstwokinds of digitalinformation,onethatencodes the proteinandRNA‘molecularmachines of life’,and the otherbeing the regulatorynetworksthatspecifyhowthesegenesareexpressed in time,spaceandamplitude.DNAinformationislayeredandarranged in ahierarchy,startingwith the gene,then ... diversity explains the meaning of whatis known in the world of mathematics asMarkovianpropertiesoperatingaspart of the dynamics of physicalandnaturalsystems. The properties...