... cross-linked hemoglobin, both smooth LPSs produced arate of oxidation faster than the corresponding rough LPSs,indicating the importance of the binding of LPS to the hemoglobin. The effect of the ... important than the lipid content of the LPS. Overall, the E. coli LPSs weremore effective than the S. minnesota LPSs in increasing the rate of oxidation, suggesting a difference in binding of the two ... displacement of superoxide during the auto-oxida-tion of Hb. In general, the increase in the oxidation rate of cross-linked Hb mediated by LPSs is due to an increase in the rate of the initial fast...