... main metabolite of aceclofenac is 4-hydroxy-aceclofenac. The other metabolites, namely diclofenac and 4-hydroxy-diclofenac, account for only 5% of the administereddose [25]. Aceclofenac acts as ... [21] diclofenac has apreference for COX-2; from this and our findings, we assumethat aceclofenac has comparable selectivity. The metabolism of aceclofenac differs from that of diclofenac and ... OAcartilage [19]. Remarkably, the effects of aceclofenac, a deri-vate of diclofenac, were similar to those of celecoxib, suggest-ing a similar mechanism of action. Based on the classificationpresented...