... susceptible to both
components.
Chapter 127. Treatment and Prophylaxis
of Bacterial Infections
(Part 3)
Inhibition of Protein Synthesis
Most of the antibacterial agents that inhibit protein ... all purines, and several amino acids. Inhibition of
folate synthesis leads to cessation of bacterial cell growth and, in some cases, to
bacterial cell death. T...
... 127- 1
Chapter 127. Treatment and Prophylaxis
of Bacterial Infections
(Part 1)
Harrison's Internal Medicine > Chapter 127. Treatment and Prophylaxis
of Bacterial Infections
Treatment ... Bacterial Infections
Treatment and Prophylaxis of Bacterial Infections: Introduction
The development of vaccines and drugs that prevent a...
...
because of a marginally broader spectrum.
Chapter 127. Treatment and Prophylaxis
of Bacterial Infections
(Part 2)
Inhibition of Cell-Wall Synthesis
One major difference between bacterial and ... any stage of the synthesis, export,
assembly, or cross-linking of peptidoglycan lead to inhibition of bacterial cell
growth and, in most cases, to cell dea...
...
penicillins and cephalosporins. One strategy that has been devised for
circumventing resistance mediated by β-lactamases is to combine the β-lactam
Chapter 127. Treatment and Prophylaxis
of Bacterial ... including nalidixic acid and its fluorinated derivatives
(ciprofloxacin, levofloxacin, and moxifloxacin), are synthetic compounds that
inhibit the activity of the A s...
... permeability and cause active drug efflux from the cytoplasm.
Mutations that result in active quinolone efflux are also found in gram-positive
bacteria.
Chapter 127. Treatment and Prophylaxis
of Bacterial ... dihydrofolate reductase for trimethoprim and an altered
dihydropteroate synthetase for sulfonamides.
Quinolones
The most common mechanism of resistance to quino...
... Chapter 127. Treatment and Prophylaxis
of Bacterial Infections
(Part 6)
Rifampin
Bacteria rapidly become resistant to rifampin by developing mutations in
the B subunit of RNA polymerase ... virtue of the acquisition of new genes include hospital-associated strains of
gram-negative bacteria, enterococci, and staphylococci and community-acquired
strains of...
... cefotaxime, rifampin, and clarithromycin, have bioactive
metabolites that may contribute to their overall efficacy.
Chapter 127. Treatment and Prophylaxis
of Bacterial Infections
(Part 7)
Distribution ... information on the mode of excretion of
an antibacterial agent is in adjusting dosage when elimination capability is
impaired (Table 127- 3). Direct, nonidio...
... indices include the ratio of the
Chapter 127. Treatment and Prophylaxis
of Bacterial Infections
(Part 8)
Principles of Antibacterial Chemotherapy
The choice of an antibacterial compound for ...
inhibition of bone
growth in fetus;
hepatotoxicity
Contraindicated
pharmacokinetic and adverse-reaction profile of active compounds, the site of
infection, th...
... to the sum of
their individual activities. Among the best examples of a synergistic or additive
Chapter 127. Treatment and Prophylaxis
of Bacterial Infections
(Part 9)
Site of Infection ... because of the relative
paucity of phagocytes and opsonins at the site of infection, the agents should be
bactericidal. Chloramphenicol, an older drug but occasionall...
...
Legionella,
Campylobacter
, and
Mycoplasma
infections;
CAP; group A
Streptococcus
Chapter 127. Treatment and Prophylaxis
of Bacterial Infections
(Part 10)
Status of the Host
Various host ...
skin and soft tissue
infections (CA-MRSA)
MRSA (3)
Sulfonamides Nocardial
infectio
ns, leprosy
(dapsone, a sulfone), and
toxoplasmosis
(sulfadiazine)
UNK...