... c-chains bind to each other through the transmembranedomain resulting in a receptor complex that is able to signalinside the cell. The nature of this binding depends onoppositely charged amino-acid ... tyrosines upon receptor cross-linking.However, it is not established whether this receptor complexis sufficient to initiate the signalling cascade. We transfectedGPVI and the FcR c-chain into the ... receptor A; PMA,phorbol myristate acetate.(Received 14 November 20 01, revised 20 March 20 02, accepted 30 April 20 02) Eur. J. Biochem. 26 9, 29 51 29 60 (20 02) Ó FEBS 20 02 doi:10.1046/j.14 32- 1033 .20 02. 029 69.xmegakaryocytic...