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Chapter 110. Coagulation Disorders
(Part 1)
Harrison's Internal Medicine > Chapter 110. Coagulation Disorders
Coagulation Disorders: Introduction
Deficiencies of coagulation ...
bleeding disorders due to deficiencies of other factors, including FII
(prothrombin), FV, FVII, FX, FXI, FXIII, and fibrinogen are usually inherited in
an autosoma...
... deficiencies of plasma coagulation are more frequent than
congenital disorders; the most common disorders include hemorrhagic diathesis of
liver disease, disseminated intravascular coagulation (DIC), ... disease, disseminated intravascular coagulation (DIC), and vitamin K
deficiency. In these disorders, blood coagulation is hampered by the deficiency of
more than one clotting...
... be tapered depending on the extent of the surgical wounds. Oral surgery is
Chapter 110. Coagulation Disorders
(Part 4)
Factor VIII and Factor IX are dosed in units. One unit is by definition
... Chapter 110. Coagulation Disorders
(Part 3)
Clinically, hemophilia A and hemophilia B are indistinguishable. The ...
patients, and the potential infectious and thrombotic risks of long-term central vein
catheters.
General considerations regarding the treatment of bleeds in hemophilia
include (1) the need to ... after major trauma or
during routine presurgery laboratory tes...
... Chapter 110. Coagulation Disorders
(Part 6)
Factor XI Deficiency: Treatment
The treatment of FXI deficiency is ...
therapy.
Other Rare Bleeding Disorders
Collectively, the inherited disorders resulting from deficiencies of clotting
factors other than FVIII, FIX, and FXI (Table 110- 1) represent a group of rare ... for plasma coagulation deficiencies are often
asym...
... Recreational drugs (amphetamines)
Envenomation
Snake
Insects
Chapter 110. Coagulation Disorders
(Part 7)
Disseminated Intravascular Coagulation
DIC is a clinicopathologic syndrome characterized ... purpura fulminans, with or without thrombosis of large
vessels.
Table 110-
2 Common Clinical Causes of Disseminated Intravascular
Coagulation
Sepsis
Bacterial
Sta...
... Chapter 110. Coagulation Disorders
(Part 8)
The central mechanism of DIC is the uncontrolled generation of thrombin
by exposure of the blood to pathologic levels of tissue factor (Fig. 110- 3). ... mediating the coagulation defects in DIC and symptoms associated
with systemic inflammatory response syndrome.
Figure 110- 3
The pathophysiology of disseminated intravas...
... membranes (Fig. 110- 2).
Inherited deficiency of the functional activity of the enzymes involved in vitamin
K metabolism, notably the GGCX or VKOR-1 (see above), results in bleeding
disorders. The ... proteases (PCCs), which further aggravates the disease.
Replacement of Coagulation or Fibrinolysis Inhibitors
Drugs to control coagulation such as heparin, antithrombin III (ATIII)
co...
... whereas acquired inhibitors are
specific to a single factor.
Further Readings
Chapter 110. Coagulation Disorders
(Part 11)
Treatment with FFP is the most effective way to correct hemostasis in ... patients.
Critical Care 10:222, 2006 [PMID: 16879728]
Mannucci PM, et al: Recessively inherited coagulation disorders.
Blood
104:1243, 2004 [PMID: 15138162]
Stafford DW: Th...