Chapter 085 Neoplasms of the Lung (Part 17) docx
Chapter 085. Neoplasms of the Lung (Part 17) docx
... Chapter 085. Neoplasms of the Lung (Part 17) Chemotherapy The chemotherapy combination most widely used for SCLC is etoposide plus ... signs of bleeding or infection, and, as required, use of hematopoietins) and adjustment of chemotherapy doses on the basis of nadir granulocyte counts are essential. The prognosis of patients ... Radiation Therapy for Palliation Palliative radiation therapy is an important component of the management of SCLC patients. Cranial radiation often decreases the signs and symptoms of brain...
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Chapter 085. Neoplasms of the Lung (Part 1) pps
... 60,514 cases of invasive lung cancer involving all races and both sexes obtained from the data for 1983–1987 of the Surveillance, Epidemiology, and End Results (SEER) Program of the National ... represents one lung cancer case for every 3 million cigarettes smoked. Thus, primary carcinoma of the lung is a major health problem with a generally grim prognosis. Pathology The term lung cancer ... tumors arising from the respiratory epithelium (bronchi, bronchioles, and alveoli). Mesotheliomas, lymphomas, and stromal tumors (sarcomas) are distinct from epithelial lung cancer. Four major...
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Chapter 085. Neoplasms of the Lung (Part 2) ppt
... smoking-related, further increases the risk of developing lung cancer. The lung cancer death rate is related to the total amount (often expressed in "cigarette pack-years") of cigarettes ... are clinically localized at the time of presentation may be cured with either surgery or radiotherapy. The beneficial role of chemotherapy in NSCLC is in palliation of symptoms and improving ... smoking. The prevalence of smoking in the United States is 28% for males and 25% for females, age 18 years or older; 38% of high school seniors smoke. The relative risk of developing lung cancer...
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Chapter 085. Neoplasms of the Lung (Part 4) pptx
... cancers other than lung cancer, nor in lung cancers that have KRAS mutations. These EGFR mutations, often associated with amplification of the EGFR gene, usually confer sensitivity of these lung ... Chapter 085. Neoplasms of the Lung (Part 4) Inherited Predisposition to Lung Cancer While an inherited predisposition to develop lung cancer is not common, several ... cases the development of EGFR TKI resistance is associated with the development of another mutation in the EGFR gene (T790M mutation), or amplification of the c-met oncogene. However, other...
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Chapter 085. Neoplasms of the Lung (Part 5) pptx
... uncommon (1%), as are the renal manifestations of nephrotic syndrome or glomerulonephritis (≤1%). Chapter 085. Neoplasms of the Lung (Part 5) Clinical Manifestations Lung cancer gives rise ... inappropriate palliative rather than curative treatment. Often the paraneoplastic syndrome may be relieved with successful treatment of the tumor. In some cases, the pathophysiology of the paraneoplastic ... and 97). Although 5–15% of patients with lung cancer are identified while they are asymptomatic, usually as a result of a routine chest radiograph or through the use of screening CT scans, most...
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Chapter 085. Neoplasms of the Lung (Part 6) doc
... one-third have Chapter 085. Neoplasms of the Lung (Part 6) Diagnosis and Staging Screening Most patients with lung cancer present with advanced disease, raising the question of whether screening ... (whether the tumor can be entirely removed by a standard surgical procedure such as a lobectomy or pneumonectomy), which depends on the anatomic stage of the tumor, and operability (whether the ... diagnosis of epithelial malignancy and distinguish small cell from non-small cell lung cancer. Staging Patients with Lung Cancer Lung cancer staging consists of two parts: first, a determination of...
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Chapter 085. Neoplasms of the Lung (Part 7) pptx
... <2 cm distal to carina but without involvement of carina; or associated atelectasis or obstructive pneumonitis of entire lung for Staging of Lung Cancer. Chest 111:1710, 1997; with permission. ... metastatic pulmonary tumor nodule(s) in the ipsilateral nonprimary tumor lobe(s) of the lung are classified as M1. Source: Adapted from CF Mountain. Revisions in the International System ... exams of a non-bloody, non-exudative pleural or pericardial effusion that clinical judgment dictates is not related to the tumor, the effusion should be excluded as a staging element and the...
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Chapter 085. Neoplasms of the Lung (Part 8) ppsx
... Chapter 085. Neoplasms of the Lung (Part 8) Small Cell Lung Cancer A simple two-stage system is used. In this system, limited-stage disease (seen in about 30% of all patients ... tuberculosis Chest x-ray CT scan of chest and abdomen CT or MRI scan of brain and radionuclide scan of bone if any finding suggests the presence of tumor metastasis in these organs Fiberoptic bronchoscopy ... examination are used in staging. In part, the definition of limited-stage disease relates to whether the known tumor can be encompassed within a tolerable radiation therapy port. Thus, contralateral...
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Chapter 085. Neoplasms of the Lung (Part 9) ppsx
... if the patient would otherwise be considered for curative treatment. In SCLC, CT scans are used in the planning of chest radiation treatment and in the assessment of the response to chemotherapy ... Regional lymph node stations for lung cancer staging. (Used by permission from CF Mountain, C Dresler: Chest 111:1718, 1997.) Chapter 085. Neoplasms of the Lung (Part 9) Chest radiographs ... involvement; old radiographs are useful for comparison. CT scans of the thorax and upper abdomen are of use in the preoperative staging of NSCLC to detect mediastinal nodes and pleural extension...
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Chapter 085. Neoplasms of the Lung (Part 10) potx
... N2 disease Stage IB: discussion of risk/benefits of adjuvant CRx; not routinely given Chapter 085. Neoplasms of the Lung (Part 10) Staging of Small Cell Lung Cancer Pretreatment staging ... MRI scan and examination of the cerebrospinal fluid cytology are performed. If malignant cells are detected, radiotherapy to the site of compression and intrathecal chemotherapy (usually with ... within 2 cm of the carina (not curable by surgery but potentially curable by radiotherapy); metastasis to the contralateral lung; bilateral endobronchial tumor (potentially curable by radiotherapy);...
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