...
22q12.2 AD Vestibular
schwannoma,
meningioma,
spine
Chapter 079. Cancer Genetics
(Part 3)
Familial Cancer Syndromes
A small fraction of cancers occur in patients with a genetic predisposition. ...
Hereditary
breast/ovarian
cancer
BRC
A1
BRC
A2
17q21
13q12.3
AD Breast,
ovarian, colon,
prostate
Hereditary
diffuse gastric
cancer
CDH
1
16q22 AD Stomach
c...
... known to be detectable by the
assay methods used).
Chapter 079. Cancer Genetics
(Part 5)
While most autosomal dominant inherited cancer syndromes are due to
mutations in tumor-suppressor ... Mendelian forms of cancer have taught us much about the
mechanisms of growth control, most forms of cancer do not follow simple patterns
of inheritance. In many instances (e.g.,...
...
Strausberg RL et al: I
n silico analysis of cancer through the Cancer
Genome Anatomy Project. Trends Cell Biol 11:S66, 2001
Chapter 079. Cancer Genetics
(Part 10)
Figure 79-8
... segregation and cancer: Cutting
through the mystery. Nat Rev Cancer 1:109, 2001 [PMID: 11905802]
Loeb LA: Mutator phenotype may be required for multistage
carcinogenesis. Cancer Res...
... malignancies.
Figure 79-2
Chapter 079. Cancer Genetics
(Part 1)
Harrison's Internal Medicine > Chapter 79. Cancer Genetics
Cancer Is a Genetic Disease
Cancer arises through a series ... consequence of these mutations in
tumor cells, is now known as cancer genetics.
The Clonal Origin and Multistep Nature of Cancer
Nearly all cancers originate from a s...
... Chapter 079. Cancer Genetics
(Part 2)
General Classes of Cancer Genes
There are two major classes of cancer genes. The first class comprises
genes ... version states that both copies of a tumor-suppressor gene must be
inactivated in cancer.
The second class of cancer genes, the caretakers, does not directly affect
cell growth but rather affects ... normal function of...
... length from chromosome to chromosome.
Chapter 079. Cancer Genetics
(Part 4)
Familial adenomatous polyposis (FAP) is a dominantly inherited colon
cancer syndrome due to germline mutations ...
dinucleotide repeats in the cancers of HNPCC patients.
Figure 79-5
Demonstration of microsatellite instability in normal and tumor tissue
from hereditary nonpolyposis colon cance...
...
progression of cancer. Noncytogenetic, molecular techniques for identifying
amplifications have more recently become available.
Numerous genes have been reported to be amplified in cancer. Several ... extends to hundreds of thousands of base pairs,
more than one oncogene may be amplified in some cancers (particularly
sarcomas). Genes simultaneously amplified in many cases include MDM2,...
... fusion protein with modified
function. (Courtesy of ER Fearon and KR Cho.)
Chapter 079. Cancer Genetics
(Part 8)
Table 79-3 Representative Oncogenes at Chromosomal Translocations
... toxicity in patients with CML. Knowledge of genetic alterations
in cancer can lead to mechanism-based design and development of cancer drugs.
Figure 79-7
Specific translocat...
... respectively. Viruses
are not sufficient for cancer development but constitute one alteration in the
multistep process of cancer.
Chapter 079. Cancer Genetics
(Part 9)
Chromosomal Instability in ... mutually exclusive in colon
cancer, suggesting that they represent alternative mechanisms for the generation of
a mutator phenotype in this cancer (Fig. 79-2). Other cancer...
... Chapter 041. Weight Loss
(Part 3)
Approach to the Patient: Weight Loss
Before extensive evaluation is undertaken, ... neoplasm. Q J Med 96: 649,
2003 [PMID: 12925720]
Inui A: Cancer anorexia-cachexia syndrome: Current issues in research and
management. Cancer J Clinicians 52:72, 2002 [PMID: 11929007]
Nora E, ... shortness of breath or cough, palpitations, and evidence of n...