...
individual will vary depending on the size of the pedigree, the number of
unaffected relatives, and the types of diagnoses, as well as the ages of disease
onset within the family. For example, ...
the relative risk ranges from two- to fivefold, underscoring the importance of
family history for these prevalent disorders. Pending further advances in genetic
test...
... management of
Chapter 064. The Practice of Genetics
in Clinical Medicine
(Part 1)
Harrison's Internal Medicine > Chapter 64. The Practice of Genetics in
Clinical Medicine
Implications of ... though they
may be seeing other specialists.
The internist has an important role in educating patients about the
indications, benefits, risks...
... undergoing the
Chapter 064. The Practice of Genetics
in Clinical Medicine
(Part 5)
Molecular analysis is generally more informative if testing is initiated in a
symptomatic family member, since ... to the child.
In addition, there is concern that testing during childhood violates a child's right to
make an informed decision regarding testing upon reachin...
... because of her family
history of cancer.
Chapter 064. The Practice of Genetics
in Clinical Medicine
(Part 3)
Recall of family history is often inaccurate. This is especially so when the
history ... cancer, representing another
confounding variable in the pedigree analysis.
Some of the aforementioned features of the family history are illustrated...
... to note that, for the majority of adult-onset, multifactorial genetic
Chapter 064. The Practice of Genetics
in Clinical Medicine
(Part 4)
Figure 64-2
disorders, testing is purely predictive. ... established disease, genetic testing for
susceptibility to chronic disease is being increasingly integrated into the practice
of medicine. In most cases, however...
... must ensure that the at-risk family members have access to
the resources necessary to adhere to these recommendations.
Chapter 064. The Practice of Genetics
in Clinical Medicine
(Part 6)
Follow-Up ... Assist in determining the role of genetic testing for the individual and
family;
Ensure that the patient is aware of the indications, process, risks,...
...
Preventio
n of
hypertension
Prevention of
urinary tract infections
Kidney
transplantation
Nephrogenic XL, AR
AVPR2,
Fluid
Chapter 064. The Practice of Genetics
in Clinical Medicine
(Part ... screening or directed
testing (Table 64 -2). Although the strategies for therapeutic interventions are best
developed for childhood hereditary metabolic diseases, the...
... Chapter 064. The Practice of Genetics
in Clinical Medicine
(Part 8)
Preventive measures and therapeutic interventions are not restricted to
metabolic disorders. Identification of familial ... genetic diagnosis of these and other disorders is only beginning
to be used in the clinical setting, predictive testing holds the promise of allowing
earlier and...
... viewed as a terminally differentiated organ without the capacity for
Chapter 067. Applications of Stem Cell
Biology in Clinical Medicine
(Part 2)
Strategies for Stem Cell Replacement
Stem ... be injected directly in the target organ or
intravenously. 2. Stem cells may be differentiated ex vivo prior to injection into
the target organ. 3. Growth factors or other d...
... Chapter 003. Decision-Making
in Clinical Medicine
(Part 2)
The following three examples introduce the subject of clinical reasoning:
A 46-year-old man presents to his internist ...
patient's clinical features match those of the class of patients with the leading
diagnostic hypotheses being considered. In other words, the clinician is searching...