... including the face, the neck, and the hands. Major risk factors include male sex, childhood sun exposures, older age, fair skin, and residence at latitudes closer to the equator. Whites of darker complexions ... but this is likely due to failure to control for confounding factors such as sunscreen stability and frequency of application. Since no prospective studies are available to address this issue, ... both a tumor initiator and a promoter. The third and final step in the malignant process is malignant conversion of benign precursors into malignant lesions, a process thought to require additional...