... precedent of, or consequence of, pancreatic cancer. Chapter 089. Pancreatic Cancer (Part 1) Harrison's Internal Medicine > Chapter 89. Pancreatic Cancer Pancreatic Cancer: Introduction ... of glucose intolerance (particularly within 2 years of cancer diagnosis), previous pancreatitis, migratory superficial thrombophlebitis (Trousseau's syndrome), gastrointestinal hemorrhage ... Heavy smokers who also have homozygous deletions of the gene for glutathione-S transferase T1 (GSTT1), a carcinogen metabolizing enzyme, may be at particular risk. Activating mutations in the K-ras...