... Chapter 017. Fever and Hyperthermia
(Part 4)
Chronology of events required for the induction of fever. AMP, adenosine
5'-monophosphate; ... prostaglandin E
2
; TNF,
tumor necrosis factor.There are four receptors for PGE
2
, and each signals the cell
in different ways. Of the four receptors, the third (EP-3) is essential for fever: ... deleted in mice, no fever...
... time; however, shivering is not
Chapter 017. Fever and Hyperthermia
(Part 1)
Harrison's Internal Medicine > Chapter 17. Fever and Hyperthermia
Fever and Hyperthermia: Introduction
Body ... also affect body
temperature
Fever versus Hyperthermia
Fever
Fever is an elevation of body temperature that exceeds the normal daily
variation and occurs in...
... individuals exercising at elevated ambient
Chapter 017. Fever and Hyperthermia
(Part 2)
Hyperthermia
Although most patients with elevated body temperature have fever, there
are circumstances in ... increased thermogenesis.
It is important to distinguish between fever and hyperthermia since
hyperthermia can be rapidly fatal and characteristically does not respond...
... required for fever production.
Chapter 017. Fever and Hyperthermia
(Part 3)
Pathogenesis of Fever
Pyrogens
The term pyrogen is used to describe any substance that causes fever.
Exogenous ... encoded by a separate gene, and each pyrogenic cytokine
has been shown to cause fever in laboratory animals and in humans. When
injected into humans, IL-1 and TNF produce...
...
membrane, and this release is the rate-limiting step in the synthesis of PGE
2
.
Therefore, inhibitors of cyclooxygenase are potent antipyretics.
Chapter 017. Fever and Hyperthermia
(Part 5)
Fever ... typhoid fever and disseminated
tuberculosis. Temperature-pulse dissociation (relative bradycardia) occurs in
typhoid fever, brucellosis, leptospirosis, some drug-indu...
... 9751057]
Chapter 017. Fever and Hyperthermia
(Part 6)
Regimens for the Treatment of Fever
The objectives in treating fever are first to reduce the elevated
hypothalamic set point and second ... Reducing fever with
antipyretics also reduces systemic symptoms of headache, myalgias, and
arthralgias.
Oral aspirin and NSAIDs effectively reduce fever but can adv...
... 2006
Schlossberg D: Fever and rash. Infect Dis Clin North Am 10:101, 1996
[PMID: 8698985]
Weber DJ et al: The acutely ill patient with fever and rash, in Principles
and Practice of Infectious ... bite and the
papule/plaque base of each vesicle. Disseminated Vibrio vulnificus infection
(Chap. 149) or ecthyma gangrenosum due to Pseudomonas aeruginosa (Chap.
Chapter 018. Feve...
... Chapter 059. Bleeding and Thrombosis
(Part 4)
Approach to the Patient: Bleeding and Thrombosis
Clinical Presentation
Disorders of hemostasis ... inherited or acquired. A detailed
personal and family history is key in determining the chronicity of symptoms and
the likelihood of the disorder being inherited and it provides clues to underlying ... clues as to the etiolog...
... constancy of S and V, S and p, T and V,
and T and p, when using the differentials dU, dH, dA, and dG, respectively. In most cases the
conditions of constant T and V or constant T and p are most ... Helmholtz energy
AUTS
(13)
and the Gibbs energy
G U pV TS H TS A pV
( 14)
Since U is a function of state, and p, V, T, and S are state variables, H, A, a...