... alter nuclear material, stimulating the formation of antinuclear antibodies and Chapter 005. Principles of Clinical Pharmacology (Part 13) Epidemiology Patients receive, on average, 10 ... tissue toxicity. Because of the reactive nature of these metabolites, covalent binding often occurs close to the site of production, typically the liver. The most common cause of drug-induced hepatotoxicity ... rash characteristic of contact dermatitis. Other types of rashes may also result from the interaction of serum factors, drugs, and sensitized lymphocytes. A small group of widely used drugs...