... approach, which is associated with high cost and a substantial risk of false-positive results. This chapter will review the basic principles of screening and prevention in the primary care setting. ... new screening test, whether based on genetic or other methods, must be subjected to rigorous evaluation of its sensitivity, specificity, impact on disease, and cost-effectiveness. Physicians and ... introduced to new screening tests, often in advance of complete evaluation. For example, the use of whole-body CT imaging has been advocated as a means to screen for a variety of disorders. Though...