... ischaemic tissue damage, and neurodegenerative con-ditions such as Alzheimer’s and Parkinson’s disease [10,11].The major calpains are l-calpain (calpain 1) andm-calpain (calpain 2), which are ... Calpains are also ofmedical importance, having been implicated in a number ofpathological conditions including: cataract formation [8],type 2 diabetes [9], muscular dystrophy, rheumatoid arth-ritis, ... proximal in the areadelineating candidate oblique-orientated a- helix-formingsegments, indicating that m-calpain domain V may containan oblique-orientated a- helix comparable to that of HA2.Consistent...