... statistical change-point detec-tion [19] and proposed a mean and variance change-pointmodel (MVCM), which brought significant improvementover many existing methods such as the CBS proposed by Olshen ... Poisson(λ2ti), i= ν +1, , ,(4)where μ1, δ ,and 2are unknown means, σ2is unknownvariance of the normal distribution, and λ1, λ ,and 2areunknown mean rates of biomarker occurrences in eachsubinterval. ... by a 2009University of Missouri Research Board (UMRB) researchGrant. H W. Deng was partially supported by grants fromNIH (nos. P50 AR055081, R01AR050496, R01AR45349, and R01AG026564) and by...