... (pro-uPA). uPA activate plasminogen a serine pro-tease that can digest ECM proteins and activate MMPs, a family of proteolytic enzymes that are also major partici-pants in ECM degradation and cancer ... 8 RESEARCH Open AccessCathepsin B: a potential prognostic marker for inflammatory breast cancerMohamed A Nouh1†, Mona M Mohamed2*†, Mohamed El-Shinawi3, Mohamed A Shaalan4, Dora Cavallo-Medved5,6,Hussein ... a rapidonset, erythema, edema of the breast and a “peau d’or-ange” appearance of the skin. High metastatic behavior (for review see [2]), rapid invasion into blood and lym-phatic vessels and...