... versatility of this platform has spawnedmultiple options for their application. For the same target and CAR recognition domain, a diversity of signalingdomains, co-expressed cytokines and anti-apoptoticgenes ... supply B7 for CD28engagement and costimulation [31]. This molecule may in principle be used in vivo to reactivate and expanddesigner T cells in conjunction with any Strategy (1 and 3,post-infusion; ... Topalian SL, Toy ST, Simon P, Lotze MT, Yang JC, Seipp CA, White DE, Steinberg SM: Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma....