... conducted a caspase activity assay. MK-4activated caspase assay in a dose-dependent manner(Fig. 2C). By contrast, vitamin K1did not show anyeffects on caspase activity and DNA fragmentation(data ... chain whereasvitamin K2has an unsaturated side chain [1].Vitamin K2acts as a cofactor for a vitamin K-dependent carboxylase involved in the carboxylationof coagulation factors and is an ... cultures.Eur J Pharmacol 263, 181–185.6 Kameda T, Miyazawa K, Mori Y, Yuasa T, ShiokawaM, Nakamaru Y, Mano H, Hakeda Y, Kameda A &Kumegawa M (1996) Vitamin K2 inhibits osteoclasticbone resorption...