... essential in order to meet basic needs,to fulfill usual roles, and to maintain health and well-being. [5 ]Quality of life (QoL) is defined as an individual'sperception of their position in life, ... the internal standard of patients,resulting in changes in the meaning of self-evaluation and hence in a possibly different experience of problems and values, such as HRQoL. HRQoL studies are influenced ... lie in measuring QoL in children, includ-ing (1) lack of consensus on suitable instruments, (2) theneed for different instruments in different age groups and (3) the need of proxy reporting...