báo cáo hóa học:" On the path to translation: Highlights fro

báo cáo hóa học:" KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells" potx

... direct action on mitochondrial membranes [19], second, by inducing mitochondrial depolarization through Bid [20], and third, by direct activation on effector caspases [21]. To fur- ther characterize ... suggests the impor- tance of identifying the molecular phenotype of the tumor prior to the initiation of therapy. Conclusion Administration of Paclitaxel to patients with hig...

Ngày tải lên : 18/06/2014, 15:20

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báo cáo hóa học:" A systematic approach to biomarker discovery; Preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers"" docx

... of samples to achieve the same statistical power according to the variance expected in the study population and its responsiveness to therapy and/or susceptibility to toxic side effects (i.e. the expected ... comparisons will be a focus of discussion. Furthermore, the definition used for the collection of clinical information or metadata derived from the bedside vary w...

Ngày tải lên : 18/06/2014, 15:20

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báo cáo hóa học: " Evaluation of adaptation to visually induced motion sickness based on the maximum cross-correlation between pulse transmission time and heart rate" docx

... this phenomenon represents an adaptation to VIMS derived from the repetitive exposure to the same swaying video image. On the other hand, TS of the 5 subjects on Day 3 were higher than on Day 1 such ... VIMS. On the other hand, an important feature of motion sickness is the adaptation process. Adaptation occurs with repetitive exposure to the motion that causes...

Ngày tải lên : 19/06/2014, 10:20

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báo cáo hóa học:" Three-dimensional growth as multicellular spheroid activates the proangiogenic phenotype of colorectal carcinoma cells via LFA-1-dependent VEGF: implications on hepatic micrometastasis" docx

... ICAM-1. In the liver, metastatic cancer cells that have survived to the cyto- toxic environment of the microvasculature start to grow in tight association to hepatic sinusoidal endothelial cells and ... incubated on 0.01% type I collagen- coated inserts with 8 μm-pores and placed on top of 2 cm 2 wells (Becton Dickinson, Madrid, Spain) containing RPMI or conditioned media f...

Ngày tải lên : 18/06/2014, 15:20

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Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc

... contexts of homeostasis and inflammation. Therefore, the waning of Treg cells, and ensuing breakdown in the self tolerance, could depend on the in situ IL-2 environment. These data all together suggest ... stabilit y and their responsiveness to the IL-2 can be controlled by different miRNA therefore opening new avenues for potential therapeutic tar- gets for the prevention and...

Ngày tải lên : 18/06/2014, 16:20

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báo cáo hóa học: " An exploratory study to evaluate the utility of an adapted Mother Generated Index (MGI) in assessment of postpartum quality of life in India" potx

... for the Mother Generated Index evaluation but 43 women from LSEC, 7 women from the MSEC and 4 women from HSEC could not be administered the ques- tionnaire. The reasons included refusal of consent, ... as a preparatory step prior to the survey. These involved asking the mothers to identify the most important positive and negative areas of their lives and to rate thei...

Ngày tải lên : 18/06/2014, 19:20

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báo cáo hóa học: " Using animal models to determine the significance of complement activation in Alzheimer''''s disease" pptx

... administration of the excitotoxin kainic acid [108,109], or injection of the neurotoxin colchicine into the dorsal hip- pocampus [109]. Surgical transection of the perforant pathway increased ... Though the acute neuronal damage in these studies differs from the chronic, progressive neu- rodegenerative process that occurs in AD, these results demonstrated that the neuronal r...

Ngày tải lên : 19/06/2014, 22:20

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Tài liệu Báo cáo khoa học: An immunomodulator used to protect young in the pouch of the Tammar wallaby, Macropus eugenii pptx

... below 100 lgÆmL )1 , and with the exception of one component, they have not been studied fur- ther. The exception is the only peptide identiﬁed (by MS ⁄ MS data) from the pouch swabs. This peptide ... lactation period [19–25]; generally the pro- tein content varies signiﬁcantly from the early to the late lactation period. Female wallabies produce a waxy secretion in the...

Ngày tải lên : 19/02/2014, 16:20

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Tài liệu Báo cáo khoa học: "Using adaptor grammars to identify synergies in the unsupervised acquisition of linguistic structure" docx

... distribution from DP(α, H) by repeatedly drawing a ball at random from the urn and then returning it plus an additional ball of the same color to the urn. In an adaptor grammar there is one DP for ... Figure 7, Consonant expands to any consonant and Vowel expands to any vowel. This grammar deﬁnes a Word to consist of up to three Syl- lables, where each Syllable consists...

Ngày tải lên : 20/02/2014, 09:20

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Báo cáo khoa học: Mercury(II) binding to metallothioneins Variables governing the formation and structural features of the mammalian Hg-MT species pptx

... by the comparison of the CD spectra of isostoichiometric species obtained under different conditions. The contribution of the counter-ion to the 3D structure of the Hg-MT aggregates is demonstrated ... does not depend on the nature of the counter-ion. Conversely, the stabilization time determines the Hg-bMTstoichiometryofmostofthe species formed and becomes particularl...

Ngày tải lên : 16/03/2014, 18:20

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báo cáo hóa học:" On the path to translation: Highlights from the 2010 Canadian Conference on Ovarian Cancer Research" pot