... findings
which indicated a marked increase in heart rate when S4
was engaged in activities such as: standing, brief periods of
walking, and extended periods of sitting while eating
(increase in ... the intensity of the activity in terms of
the cardiorespiratory response. Ambulatory physiological
monitoring of individuals with stroke throughout the day
may provide a method...
... that selected sigma-2
ligands are capable of inducing apoptosis in a multitude
of human and murine cancer cells lines and in animal
models of cancer including pancreas cancer [12,13,15].
The mechanisms ... considerable interest in stimulating apoptosis and
inhibiting survival machinery as components of cancer
therapy [4-6]. Many oncogenic transformations result
from the inacti...
...
in the cancer nest; (C) and (D): the staining of CD133 on the
luminal surface and the basal surface of cancer cells; (E): the
staining of CD133 on budding cancer nest; (F): the staining of ... normal intestinal epithelium could be found in
72 out of 104 specimens used for this study. The CD133
expression of normal intestinal epithelium was only
found in 7 out of the 72 s...
... accuracy of urinary
cytology in daily practice. Cancer 1999, 87:118-128.
9. Kriegmair M, Knuchel R, Stepp H, Hofstaedter F, Hofstetter A: Detection of
early bladder cancer by 5-aminolevulinic acid induced ... detection of urothelial
carcinoma in situ with hexaminolevulinate fluorescence cystoscopy. J
Urol 2004, 171(1):135-8.
15. Algaba F, Amin M, et al: Tumours of the urinary syst...
... targeting checkpoint kinase 1 (CHK1). Validation of the screening results was performed in MIA
PaCa-2 and BxPC3 pancreatic cancer cells by examining the dose response of gemcitabine treatment in
the ... combination of gemcitabine and CHK1 inhibitors as
a potential treatment for pancreatic cancer patients. The
preclinical finding of inhibition of CHK1 as a sensitizing
target for...
... +3 for increas ing intensity and “ continuity” of stain-
ing of the cell membrane[17]. For quantification of Her3
staining, we scored two compartmen ts of the cell - the
cell membrane, using the ... extracellular
ligand-binding domain, a transmembrane domain, and
an intracytoplas mic tyrosine kinase domain[3-5]. Ligand
binding to these receptors induces the formation of
* Correspond...
... participated in the design of the study, was
involved in collection of blood samples and performed
ApoE genotyping; MC participated in the design of the
study, was involved in clinical examinations ... have no competing inter-
ests.
Cumulative survival of patients with Alzheimer's disease with low (solid line) and high (dashed line) initial AOC levelsFigure 2
Cumulative...
... studies [27], while in our study of test-retest reliabil-
ity, only 27 participants were included. SDD
ind
estimated
in sample 2 were in line with the initial findings in the
DHI (SDD ≥ 18) [1]. However, ... the appointment for interview and baseline test-
ing. A second test including all measures was adminis-
tered about 6 months later, using the same test procedure.
The same ph...
... Effect of imatinib
on proliferation).
Dasatinib in combination with chemotherapy
The effect of dasatinib in combination with chemother-
apy was examined in the three dasatinib responsive cell
lines, ... clinical trials of dasatinib in melanoma are currently
underway, including a phase I/II study of dasatinib in
combination with dacarbazine http://www.clinicaltri
als.gov.
Con...
... Trend in a single patient; (B) trend of the average value of Treg cells during HDI IV
treatment; (C) Boxplot summarizing the data observed in the cohort of patients during the initial 4 weeks of ... circulating Treg cells (CD4+CD25+FoxP3+) in the blood of melanoma patients during the four weeks of HDI IV induction therapyFigure 1
A-B-C. Levels of circulating Treg cells...